WormBase Tree Display for Gene: WBGene00017033

WBGene00017033 SMap: S_parent: Sequence: D1044
  Identity: Version: 2
    Name: CGC_name: nekl-4 Person_evidence: WBPerson353
      Sequence_name: D1044.8
      Molecular_name: D1044.8
        D1044.8.1
        CE39141
      Other_name: CELE_D1044.8 Accession_evidence: NDB BX284603
      Public_name: nekl-4
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 16 Feb 2007 14:39:36 WBPerson2970 Name_change: CGC_name: nekl-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nekl
    Allele (64)
    Possibly_affected_by: WBVar02153289
      WBVar02153290
    Strain: WBStrain00051867
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (34)
    Paralog: WBGene00021461 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017578 Caenorhabditis elegans From_analysis: Panther
      WBGene00008956 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013694 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020324 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022631 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle G2/M phase transition. Expressed in PQR; amphid neurons; ciliated neurons; and phasmid neurons. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 44. Is an ortholog of human NEK10 (NIMA related kinase 10). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111851 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18592)
  Molecular_info: Corresponding_CDS: D1044.8
    Corresponding_CDS_history: D1044.8:wp149
    Corresponding_transcript: D1044.8.1
    Other_sequence: JI168894.1
      EY459640.1
      FC546807.1
      Oden_isotig22119
      FC541556.1
      Acan_isotig09333
      ACC12546_1
    Associated_feature: WBsf717903
      WBsf992418
      WBsf992419
      WBsf992420
      WBsf992421
      WBsf1014899
      WBsf226689
      WBsf226690
  Experimental_info: RNAi_result: WBRNAi00043375 Inferred_automatically: RNAi_primary
      WBRNAi00012516 Inferred_automatically: RNAi_primary
      WBRNAi00007279 Inferred_automatically: RNAi_primary
      WBRNAi00005238 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr15275
      Expr15276
      Expr1020639
      Expr1147360
      Expr2013955
      Expr2032194
    Drives_construct: WBCnstr00027620
      WBCnstr00042153
    Construct_product: WBCnstr00027620
      WBCnstr00042153
    Microarray_results (15)
    Expression_cluster: WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:all-neurons_larva_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_embryo_SelectivelyEnriched
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045861:wdr-5(ok1417)_upregulated
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:csr-1(RNAi)_upregulated_Set2
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055103:thoc-5(wy822)_upregulated
      WBPaper00055226:adr-1(tm668)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056284:ints-5(RNAi)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:ASJ
      WBPaper00061340:ASK
      WBPaper00061340:AVG
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061651:ASH_enriched
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061902:camt-1(ok515)_regulated_AFD
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:25_0
      WBPaper00065841:25_1
      WBPaper00065841:28_0
      WBPaper00065841:29_0
      WBPaper00065841:36_0
      WBPaper00065841:36_2
      WBPaper00065841:36_3
      WBPaper00065841:39_1
      WBPaper00065841:39_2
      WBPaper00065841:39_3
      WBPaper00065841:47_0
      WBPaper00065841:47_1
      WBPaper00065841:63_0
      WBPaper00065841:72_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00026929:sir-2.1_overexpression_regulated
    Interaction: WBInteraction000469126
  Map_info: Map: III Position: -1.57363 Error: 0.01134
    Positive: Positive_clone: D1044 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00057688
    WBPaper00057832
    WBPaper00060497
    WBPaper00061850
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene