WormBase Tree Display for Gene: WBGene00017028
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| WBGene00017028 | SMap | S_parent | Sequence | D1044 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dex-1 | Paper_evidence | WBPaper00033050 | |||||
| Person_evidence | WBPerson576 | ||||||||
| Sequence_name | D1044.2 | ||||||||
| Molecular_name | D1044.2a | ||||||||
| D1044.2a.1 | |||||||||
| CE44889 | |||||||||
| D1044.2b | |||||||||
| CE44959 | |||||||||
| D1044.2c | |||||||||
| CE45008 | |||||||||
| D1044.2b.1 | |||||||||
| D1044.2c.1 | |||||||||
| Other_name | CELE_D1044.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | dex-1 | ||||||||
| DB_info | Database | AceView | gene | 3G623 | |||||
| WormQTL | gene | WBGene00017028 | |||||||
| WormFlux | gene | WBGene00017028 | |||||||
| NDB | locus_tag | CELE_D1044.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00017028|UniProtKB=P41950 | |||||||
| family | PTHR24039 | ||||||||
| NCBI | gene | 175761 | |||||||
| RefSeq | protein | NM_065780.6 | |||||||
| NM_065781.6 | |||||||||
| NM_001392098.1 | |||||||||
| SwissProt | UniProtAcc | P41950 | |||||||
| TREEFAM | TREEFAM_ID | TF335195 | |||||||
| UniProt_GCRP | UniProtAcc | P41950 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 30 Aug 2012 13:01:18 | WBPerson2970 | Event | Acquires_merge | WBGene00044269 | ||||
| Name_change | CGC_name | dex-1 | |||||||
| Acquires_merge | WBGene00044269 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dex | ||||||||
| Allele (123) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (29) | |||||||||
| Structured_description | Concise_description | dex-1 encodes a single-pass transmembrane protein with a domain similar to zonaadhesion, a sperm protein that binds the ZP matrix, dex-1 is also predicted to include two domains similar to nidogens, a family of proteins found in especially neural basement membrane; dex-1 share a domain composition with alpha and beta; tectorin, two vertebrate inner ear protein found in matrix that anchors the sensory endings of hair cells and is required for hearing; dex-1 genetically interacts with dyf-7 suggesting a similarity in function between DEX-1, DYF-7 and a-tectorin; dex-1 and dyf-7 activities are necessary and sufficient at the time of dendrite extension; dex-1 phenotype is specific to lengths of the dendrites and sheath glial process; dex-1 and dyf-7 mutations cause defects at 2 steps, first in establishing proper dendrite length during embryonic development and second in scaling dendrite length to keep pace with larval growth; dex-1 an dyf-7 is required for setting the absolute length of the dendritic-glial bundle and in mutants all 12 dendrites and the sheath glial process fail to extend to the tip of the nose; DEX-1 and DYF-7 are secreted for dendrite anchoring; dex-1 promoter is expressed in many non-neuronal adjacent cells, including hypodermal cells, seen as a row lateral to the amphid neuron bundle and, in separate group, surrounding the sensory depression at the anterior pole of the embryo, also drive expression in the excretory cell; DEX-1-mcherry localizes in spots and patches restricted to head and tail where sensory organs are forming; occasionally colocalizes with DYF-7-GFP at dendritic tips. | Paper_evidence | WBPaper00033050 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 20 May 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable calcium ion binding activity. Involved in amphid sensory organ dendrite retrograde extension. Located in dendrite membrane. Expressed in several structures, including anterior deirid sensillum; excretory system; pharynx; rectum; and socket cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | D1044.2a | |||||||
| D1044.2b | |||||||||
| D1044.2c | |||||||||
| Corresponding_CDS_history | D1044.2a:wp154 | ||||||||
| D1044.2b:wp214 | |||||||||
| Corresponding_transcript | D1044.2a.1 | ||||||||
| D1044.2b.1 | |||||||||
| D1044.2c.1 | |||||||||
| Other_sequence | BUC00544_1 | ||||||||
| JI164513.1 | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00093012 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00030334 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066041 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005972 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012515 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043370 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3888 | ||||||||
| Expr13993 | |||||||||
| Expr13994 | |||||||||
| Expr14573 | |||||||||
| Expr14574 | |||||||||
| Expr1025013 | |||||||||
| Expr1037319 | |||||||||
| Expr1147354 | |||||||||
| Expr2010861 | |||||||||
| Expr2029099 | |||||||||
| Drives_construct | WBCnstr00011720 | ||||||||
| WBCnstr00027625 | |||||||||
| WBCnstr00040516 | |||||||||
| WBCnstr00040517 | |||||||||
| WBCnstr00041170 | |||||||||
| Construct_product | WBCnstr00027625 | ||||||||
| WBCnstr00040517 | |||||||||
| Microarray_results (37) | |||||||||
| Expression_cluster (220) | |||||||||
| Interaction | WBInteraction000277489 | ||||||||
| WBInteraction000343266 | |||||||||
| Map_info | Map | III | Position | -1.56394 | |||||
| Positive | Positive_clone | D1044 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
