WormBase Tree Display for Gene: WBGene00014025
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| WBGene00014025 | SMap | S_parent | Sequence | ZK637 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | asna-1 | Paper_evidence | WBPaper00029101 | |||||
| Person_evidence | WBPerson304 | ||||||||
| WBPerson664 | |||||||||
| Sequence_name | ZK637.5 | ||||||||
| Molecular_name | ZK637.5 | ||||||||
| ZK637.5.1 | |||||||||
| CE00436 | |||||||||
| Other_name | tag-205 | Person_evidence | WBPerson201 | ||||||
| CELE_ZK637.5 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | asna-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 22 Dec 2004 16:59:41 | WBPerson2970 | Name_change | CGC_name | tag-205 | ||||
| 3 | 16 Feb 2007 14:39:36 | WBPerson2970 | Name_change | CGC_name | asna-1 | ||||
| Other_name | tag-205 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | asna | ||||||||
| Allele (25) | |||||||||
| Strain | WBStrain00035475 | ||||||||
| WBStrain00035956 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Contained_in_operon | CEOP3552 | ||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00014987 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | |||||
| Structured_description | Concise_description | asna-1 encodes a putative membrane transporter that is required,non-cell-autonomously, for L1 larvae to proceed through development whenfed, and is also required for normal insulin (DAF-28) secretion; thehuman ASNA1 ortholog stimulates insulin secretion in pancreatic betacells, and can transgenically rescue asna-1 mutant C. elegans,suggesting that ASNA-1's function is conserved among metazoa; asna-1mutants only progress to adulthood when rescued by maternal ASNA-1;without maternal rescue, asna-1 mutants eat food and endocytosenutrients normally, but nevertheless arrest growth as L1 larvae andlocalize DAF-16 to the nucleus as if food were absent; asna-1 isexpressed in some sensory neurons, in insulin-producing intestinalcells, and in hypodermis; ASNA-1 positively regulates dauer exit in thesame way that overexpression of the insulins DAF-28 or INS-4 does, andrequires DAF-28 to do this efficiently; ASNA-1 has ATPase activity invitro, and this activity is required for transgenic rescue of asna-1mutations. | Paper_evidence | WBPaper00029101 | |||||
| WBPaper00029103 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 18 Feb 2007 00:00:00 | ||||||||
| Automated_description | Enables ATP hydrolysis activity. Involved in detoxification of arsenic-containing substance and positive regulation of insulin secretion. Located in axon and neuronal cell body. Expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and reproductive system. Used to study cancer. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Is an ortholog of human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00061328 | ||||
| WBPaper00037696 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Oct 2021 00:00:00 | ||||||||
| Potential_model | DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:752) | |||||
| Models_disease_asserted | WBDOannot00001066 | ||||||||
| WBDOannot00001067 | |||||||||
| Molecular_info | Corresponding_CDS | ZK637.5 | |||||||
| Corresponding_transcript | ZK637.5.1 | ||||||||
| Other_sequence (83) | |||||||||
| Associated_feature | WBsf034286 | ||||||||
| WBsf993507 | |||||||||
| WBsf993508 | |||||||||
| WBsf1015509 | |||||||||
| WBsf1015510 | |||||||||
| WBsf225487 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00103076 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00005059 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103074 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103075 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038387 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103072 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059596 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00000434 | ||||||||
| WBCnstr00002653 | |||||||||
| WBCnstr00004628 | |||||||||
| WBCnstr00004629 | |||||||||
| WBCnstr00012077 | |||||||||
| WBCnstr00029370 | |||||||||
| Construct_product | WBCnstr00000434 | ||||||||
| WBCnstr00004628 | |||||||||
| WBCnstr00004629 | |||||||||
| WBCnstr00012077 | |||||||||
| WBCnstr00029370 | |||||||||
| Regulate_expr_cluster | WBPaper00065132:asna-1(ok938)_downregulated_protein | ||||||||
| WBPaper00065132:asna-1(ok938)_upregulated_protein | |||||||||
| Antibody | WBAntibody00001229 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (90) | |||||||||
| Interaction (105) | |||||||||
| Anatomy_function | WBbtf0042 | ||||||||
| WBbtf0043 | |||||||||
| WBbtf0044 | |||||||||
| WBbtf0045 | |||||||||
| Map_info | Map | III | Position | -0.009601 | Error | 0.001135 | |||
| Positive | Positive_clone | ZK637 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4957 | |||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
