WormBase Tree Display for Gene: WBGene00012885
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| WBGene00012885 | SMap | S_parent | Sequence | Y45F10D | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | iscu-1 | |||||||
| Sequence_name | Y45F10D.4 | ||||||||
| Molecular_name | Y45F10D.4 | ||||||||
| Y45F10D.4.1 | |||||||||
| CE16643 | |||||||||
| Other_name | CELE_Y45F10D.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | iscu-1 | ||||||||
| DB_info | Database | AceView | gene | 4O549 | |||||
| WormQTL | gene | WBGene00012885 | |||||||
| WormFlux | gene | WBGene00012885 | |||||||
| NDB | locus_tag | CELE_Y45F10D.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00012885|UniProtKB=O45948 | |||||||
| family | PTHR10093 | ||||||||
| NCBI | gene | 178344 | |||||||
| RefSeq | protein | NM_070257.4 | |||||||
| TREEFAM | TREEFAM_ID | TF105422 | |||||||
| TrEMBL | UniProtAcc | O45948 | |||||||
| UniProt_GCRP | UniProtAcc | O45948 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 14 Mar 2019 16:17:45 | WBPerson1983 | Name_change | CGC_name | iscu-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | iscu | ||||||||
| Allele (19) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (39) | |||||||||
| Structured_description | Concise_description | Y45F10D.4 encodes a putative iron-sulfur cluster assembly enzyme that is required for embryonic and larval viability, and that is orthologous to human NIFUN and budding yeast ISU1 and ISU2; Y45F10D.4 expression levels are unusually stable, with relatively little variation between adults, dauers, and L3 larvae, or between wild-type and daf-2(e1370ts) or daf-16(m26) mutant adults; by orthology with yeast ISU1, Y45F10D.4 is predicted to bind FRH-1. | Paper_evidence | WBPaper00006395 | |||||
| WBPaper00025054 | |||||||||
| WBPaper00031448 | |||||||||
| WBPaper00031518 | |||||||||
| WBPaper00031519 | |||||||||
| WBPaper00031520 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Feb 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable 2 iron, 2 sulfur cluster binding activity and ferrous iron binding activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be located in mitochondrial matrix. Expressed in body wall musculature and hypodermis. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma and pre-eclampsia. Is an ortholog of human ISCU (iron-sulfur cluster assembly enzyme). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29882) | ||||
| DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29882) | ||||||
| Molecular_info | Corresponding_CDS | Y45F10D.4 | |||||||
| Corresponding_transcript | Y45F10D.4.1 | ||||||||
| Other_sequence (68) | |||||||||
| Associated_feature | WBsf646539 | ||||||||
| WBsf019655 | |||||||||
| WBsf229458 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00026708 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00037100 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00098387 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00088549 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00037096 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056598 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056603 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr15935 | ||||||||
| Expr15936 | |||||||||
| Expr1022523 | |||||||||
| Expr1035697 | |||||||||
| Expr1160071 | |||||||||
| Expr2007551 | |||||||||
| Expr2025787 | |||||||||
| Drives_construct | WBCnstr00029801 | ||||||||
| WBCnstr00042612 | |||||||||
| Construct_product | WBCnstr00029801 | ||||||||
| WBCnstr00042613 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (72) | |||||||||
| Interaction (46) | |||||||||
| WBProcess | WBbiopr:00000096 | ||||||||
| Map_info | Map | IV | Position | 10.8556 | |||||
| Positive | Positive_clone | Y45F10D | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
