WormBase Tree Display for Gene: WBGene00012386
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| WBGene00012386 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | agef-1 | Person_evidence | WBPerson3858 | |||||
| Sequence_name | Y6B3A.1 | ||||||||
| Molecular_name | Y6B3A.1a | ||||||||
| Y6B3A.1a.1 | |||||||||
| CE42203 | |||||||||
| Y6B3A.1b | |||||||||
| CE36249 | |||||||||
| Y6B3A.1b.1 | |||||||||
| Other_name | CELE_Y6B3A.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | agef-1 | ||||||||
| DB_info | Database | AceView | gene | 1O196 | |||||
| WormQTL | gene | WBGene00012386 | |||||||
| WormFlux | gene | WBGene00012386 | |||||||
| NDB | locus_tag | CELE_Y6B3A.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00012386|UniProtKB=G5EFH7 | |||||||
| family | PTHR10663 | ||||||||
| NCBI | gene | 173231 | |||||||
| RefSeq | protein | NM_001026627.8 | |||||||
| NM_001026628.5 | |||||||||
| TrEMBL | UniProtAcc | Q7K783 | |||||||
| G5EFH7 | |||||||||
| UniProt_GCRP | UniProtAcc | G5EFH7 | |||||||
| OMIM | gene | 605371 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 17 Sep 2007 11:56:36 | WBPerson2970 | Name_change | CGC_name | agef-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | agef | ||||||||
| Allele (271) | |||||||||
| Strain | WBStrain00036479 | ||||||||
| WBStrain00031264 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00018184 | ||||||||
| 00119537 | |||||||||
| 00119538 | |||||||||
| Contained_in_operon | CEOP1712 | ||||||||
| CEOP1708 | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00013223 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00019726 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001743 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007703 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008685 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | agef-1 encodes a putative ARF guanine nucleotide exchange factor orthologous to human ARFGEF1 (OMIM:604141) and ARFGEF2 (OMIM:605371); agef-1(RNAi) inhibits CAV-1 body formation in oocytes more severely than arf-1 disruption alone, indicating that activation of both ARF-1 and ARF-3 by AGEF-1 may be required for transport of caveolin from Golgi to CAV-1 bodies during oogenesis; more generally, AGEF-1 is required in mass RNAi assays for embryonic and larval viability, embryonic osmotic integrity, normal neurotransmission, locomotion, and osmoregulation, and normally rapid growth. | Paper_evidence | WBPaper00004402 | |||||
| WBPaper00006395 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00026667 | |||||||||
| WBPaper00027612 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 31 Oct 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in protein transport and regulation of ARF protein signal transduction. Expressed in coelomocyte; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is an ortholog of human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050454 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15853) | ||||
| Molecular_info | Corresponding_CDS | Y6B3A.1a | |||||||
| Y6B3A.1b | |||||||||
| Corresponding_CDS_history | Y6B3A.1a:wp187 | ||||||||
| Y6B3A.1c:wp235 | |||||||||
| Corresponding_transcript | Y6B3A.1a.1 | ||||||||
| Y6B3A.1b.1 | |||||||||
| Other_sequence (59) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern | Expr10012 | ||||||||
| Expr1016666 | |||||||||
| Expr1035488 | |||||||||
| Expr1161500 | |||||||||
| Expr2009260 | |||||||||
| Expr2027497 | |||||||||
| Drives_construct | WBCnstr00015004 | ||||||||
| Construct_product | WBCnstr00019911 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (98) | |||||||||
| Interaction (109) | |||||||||
| Map_info | Map | I | Position | 21.5851 | Error | 0.012671 | |||
| Positive | Positive_clone | Y6B3A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
