WormBase Tree Display for Gene: WBGene00012236
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| WBGene00012236 | SMap | S_parent | Sequence | W04A8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | Sequence_name | W04A8.1 | |||||||
| Molecular_name | W04A8.1a | ||||||||
| W04A8.1a.1 | |||||||||
| CE54458 | |||||||||
| W04A8.1b | |||||||||
| CE54517 | |||||||||
| W04A8.1c | |||||||||
| CE54409 | |||||||||
| W04A8.1b.1 | |||||||||
| W04A8.1c.1 | |||||||||
| Other_name | CELE_W04A8.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | W04A8.1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Allele (103) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00006085 | ||||||||
| 00006086 | |||||||||
| 00101872 | |||||||||
| 00101873 | |||||||||
| 00101874 | |||||||||
| 00119392 | |||||||||
| Contained_in_operon | CEOP1724 | ||||||||
| Ortholog (26) | |||||||||
| Paralog | WBGene00009479 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | W04A8.1 encodes a protein weakly similar to human microcephalin (MCPH1; OMIM:607117, mutated in primary microcephaly); while their primary sequence similarity is very subtle (only being detectable with psi-BLAST on NCBI-nr, using C. briggsae CBG13622 as a query sequence), both W04A8.1 and microcephalin has similar ordering of BRCT domains (one N-terminal, two C-terminal); W04A8.1 has no obvious function in mass RNAi screens. | Paper_evidence | WBPaper00004402 | |||||
| WBPaper00013074 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer; and primary autosomal recessive microcephaly 1. Is an ortholog of human MCPH1 (microcephalin 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6954) | ||||
| DOID:0070285 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6954) | ||||||
| DOID:4451 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6954) | ||||||
| DOID:10907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6954) | ||||||
| DOID:0070296 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6954) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6954) | ||||||
| DOID:1380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6954) | ||||||
| Molecular_info | Corresponding_CDS | W04A8.1a | |||||||
| W04A8.1b | |||||||||
| W04A8.1c | |||||||||
| Corresponding_CDS_history | W04A8.1a:wp282 | ||||||||
| W04A8.1b:wp282 | |||||||||
| Corresponding_transcript | W04A8.1a.1 | ||||||||
| W04A8.1b.1 | |||||||||
| W04A8.1c.1 | |||||||||
| Other_sequence | CR04248 | ||||||||
| CR09081 | |||||||||
| CRC08556_1 | |||||||||
| PT01608 | |||||||||
| PT04484 | |||||||||
| CR09080 | |||||||||
| CBC09019_1 | |||||||||
| Associated_feature | WBsf649721 | ||||||||
| WBsf665085 | |||||||||
| WBsf665086 | |||||||||
| WBsf985956 | |||||||||
| WBsf220550 | |||||||||
| WBsf220551 | |||||||||
| WBsf220552 | |||||||||
| WBsf220553 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00062400 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00054743 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036260 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004412 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1026899 | ||||||||
| Expr1035417 | |||||||||
| Expr1158281 | |||||||||
| Expr2006755 | |||||||||
| Expr2024976 | |||||||||
| Drives_construct | WBCnstr00030053 | ||||||||
| Construct_product | WBCnstr00030053 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (170) | |||||||||
| Interaction | WBInteraction000032332 | ||||||||
| WBInteraction000544677 | |||||||||
| Map_info | Positive | Positive_clone | W04A8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Interpolated_map_position | I | 22.005 | |||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00055090 | |||||||||
| Method | Gene |
