WormBase Tree Display for Gene: WBGene00012004
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| WBGene00012004 | SMap | S_parent | Sequence | T24H10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dyrb-1 | Person_evidence | WBPerson3088 | |||||
| Sequence_name | T24H10.6 | ||||||||
| Molecular_name | T24H10.6 | ||||||||
| T24H10.6.1 | |||||||||
| CE03731 | |||||||||
| Other_name | CELE_T24H10.6 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | dyrb-1 | ||||||||
| DB_info | Database | AceView | gene | 2J396 | |||||
| WormQTL | gene | WBGene00012004 | |||||||
| WormFlux | gene | WBGene00012004 | |||||||
| NDB | locus_tag | CELE_T24H10.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00012004|UniProtKB=Q22752 | |||||||
| family | PTHR10779 | ||||||||
| NCBI | gene | 188872 | |||||||
| RefSeq | protein | NM_063542.7 | |||||||
| TREEFAM | TREEFAM_ID | TF315165 | |||||||
| TrEMBL | UniProtAcc | Q22752 | |||||||
| UniProt_GCRP | UniProtAcc | Q22752 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 01 Apr 2005 11:05:24 | WBPerson2970 | Name_change | CGC_name | dyrb-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dyrb | ||||||||
| Allele (11) | |||||||||
| Strain | WBStrain00036613 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP2412 | ||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | dyrb-1 encodes a small (95-residue) putative cytoplasmic dynein light chain 2A that inhibits DHC-1 in vivo, and is also required for mitotic spindle positioning, embryonic viability and fertility; DYRB-1 is orthologous to Drosophila ROADBLOCK (and six Drosophila paralogs), Chlamydomonas LC7, human DYNLRB1 (OMIM:607167), and human DYNLRB2 (OMIM:607168); dyrb-1(RNAi) and dyrb-1(tm2645) both suppress the lethality of conditional dhc-1 mutations, and dyrb-1(RNAi) suppresses dhc-1(or195) spindle length and cytokinesis defects as well, indicating that DYRB-1 negatively regulates dynein; in oocytes and early embryos, DYRB-1 is associated with nuclear envelopes and centrosomes, and with meiotic and mitotic spindle poles; like DHC-1 itself, DYRB-1 is strongly mislocalized to centrosomes in dhc-1(or195) animals shifted to nonpermissive temperature. | Paper_evidence | WBPaper00024925 | |||||
| WBPaper00025054 | |||||||||
| WBPaper00030897 | |||||||||
| WBPaper00030908 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 26 Aug 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Located in several cellular components, including cell cortex; microtubule cytoskeleton; and perinuclear region of cytoplasm. Expressed in ciliated neurons and intestine. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is an ortholog of human DYNLRB1 (dynein light chain roadblock-type 1) and DYNLRB2 (dynein light chain roadblock-type 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15467,HGNC:15468) | ||||
| Molecular_info | Corresponding_CDS | T24H10.6 | |||||||
| Corresponding_transcript | T24H10.6.1 | ||||||||
| Other_sequence (37) | |||||||||
| Associated_feature | WBsf223604 | ||||||||
| WBsf223605 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00091216 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00108763 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061553 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00035938 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090798 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082364 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091217 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054085 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108797 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019178 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4800 | ||||||||
| Expr4893 | |||||||||
| Expr9178 | |||||||||
| Expr9587 | |||||||||
| Expr1013476 | |||||||||
| Expr1035306 | |||||||||
| Expr1157628 | |||||||||
| Expr2011143 | |||||||||
| Expr2029379 | |||||||||
| Drives_construct | WBCnstr00013772 | ||||||||
| WBCnstr00014151 | |||||||||
| WBCnstr00030208 | |||||||||
| Construct_product | WBCnstr00001416 | ||||||||
| WBCnstr00004965 | |||||||||
| WBCnstr00007750 | |||||||||
| WBCnstr00013772 | |||||||||
| WBCnstr00030208 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (109) | |||||||||
| Interaction (48) | |||||||||
| Map_info | Map | II | Position | 1.03536 | Error | 0.005303 | |||
| Positive | Positive_clone | T24H10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5255 | |||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
