WormBase Tree Display for Gene: WBGene00011559
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WBGene00011559 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||||
Name | CGC_name | umps-1 | Person_evidence | WBPerson253 | |||||
Sequence_name | T07C4.1 | ||||||||
Molecular_name (3) | |||||||||
Other_name | rad-6 | ||||||||
CELE_T07C4.1 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | umps-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 01 Aug 2008 11:47:51 | WBPerson2970 | Name_change | CGC_name | umps-1 | ||||
3 | 12 Nov 2014 11:48:46 | WBPerson2970 | Event | Acquires_merge | WBGene00004292 | ||||
Name_change | Other_name | rad-6 | |||||||
Acquires_merge | WBGene00004292 | ||||||||
Status | Live | ||||||||
Gene_info (12) | |||||||||
Disease_info | Experimental_model | DOID:0050833 | Homo sapiens | Paper_evidence | WBPaper00035924 | ||||
WBPaper00044506 | |||||||||
Accession_evidence | OMIM | 258900 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 24 Apr 2017 00:00:00 | ||||||||
Potential_model | DOID:653 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12563) | |||||
DOID:0050833 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12563) | ||||||
Disease_relevance | Human Uridine monophosphate synthetase (UMPS) catalyses the last step of pyrimidine nucleotide synthesis which involves the conversion of orotate to uridine monophosphate (UMP); mutations in UMPS lead to Orotic aciduria; Orotic aciduria results in megaloblastic anemia and is associated with physical and mental retardation; in C. elegans, the loss of the bifunctional UMP synthase protein, umps-1, which carries catalytic activities for OPRTase (orotate phosphoribosyltransferase) and ODCase (orotate monophosphate decarboxylase) leads to both hypersensitivity to radiation and a decline in both metabolic rate and lifespan. | Homo sapiens | Paper_evidence | WBPaper00035924 | |||||
Accession_evidence | OMIM | 258900 | |||||||
613891 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 24 Apr 2017 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000005 | ||||||||
WBDOannot00000411 | |||||||||
Molecular_info | Corresponding_CDS | T07C4.1 | |||||||
Corresponding_transcript | T07C4.1.1 | ||||||||
Other_sequence (23) | |||||||||
Associated_feature | WBsf993989 | ||||||||
WBsf993990 | |||||||||
WBsf993991 | |||||||||
WBsf1015775 | |||||||||
WBsf227444 | |||||||||
WBsf227445 | |||||||||
WBsf227446 | |||||||||
Experimental_info | RNAi_result (56) | ||||||||
Expr_pattern | Expr8781 | ||||||||
Expr12838 | |||||||||
Expr1016073 | |||||||||
Expr1035094 | |||||||||
Expr1156331 | |||||||||
Expr2017831 | |||||||||
Expr2035967 | |||||||||
Drives_construct | WBCnstr00007424 | ||||||||
WBCnstr00013520 | |||||||||
WBCnstr00030561 | |||||||||
Construct_product | WBCnstr00030561 | ||||||||
Microarray_results (21) | |||||||||
Expression_cluster (173) | |||||||||
Interaction (115) | |||||||||
Map_info | Map | III | Position | 2.47257 | Error | 0.002259 | |||
Positive | Positive_clone | T07C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (16) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |