WormBase Tree Display for Gene: WBGene00011559

WBGene00011559 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity (6)
  Gene_info (12)
  Disease_info: Experimental_model: DOID:0050833 Homo sapiens Paper_evidence: WBPaper00035924
            WBPaper00044506
          Accession_evidence: OMIM 258900
          Curator_confirmed: WBPerson324
          Date_last_updated: 24 Apr 2017 00:00:00
    Potential_model: DOID:653 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12563)
      DOID:0050833 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12563)
    Disease_relevance: Human Uridine monophosphate synthetase (UMPS) catalyses the last step of pyrimidine nucleotide synthesis which involves the conversion of orotate to uridine monophosphate (UMP); mutations in UMPS lead to Orotic aciduria; Orotic aciduria results in megaloblastic anemia and is associated with physical and mental retardation; in C. elegans, the loss of the bifunctional UMP synthase protein, umps-1, which carries catalytic activities for OPRTase (orotate phosphoribosyltransferase) and ODCase (orotate monophosphate decarboxylase) leads to both hypersensitivity to radiation and a decline in both metabolic rate and lifespan. Homo sapiens Paper_evidence: WBPaper00035924
          Accession_evidence: OMIM 258900
              613891
          Curator_confirmed: WBPerson324
          Date_last_updated: 24 Apr 2017 00:00:00
  Models_disease_asserted: WBDOannot00000005
    WBDOannot00000411
  Molecular_info: Corresponding_CDS: T07C4.1
    Corresponding_transcript: T07C4.1.1
    Other_sequence (23)
    Associated_feature: WBsf993989
      WBsf993990
      WBsf993991
      WBsf1015775
      WBsf227444
      WBsf227445
      WBsf227446
  Experimental_info: RNAi_result (56)
    Expr_pattern: Expr8781
      Expr12838
      Expr1016073
      Expr1035094
      Expr1156331
      Expr2017831
      Expr2035967
    Drives_construct: WBCnstr00007424
      WBCnstr00013520
      WBCnstr00030561
    Construct_product: WBCnstr00030561
    Microarray_results (21)
    Expression_cluster (173)
    Interaction (115)
  Map_info: Map: III Position: 2.47257 Error: 0.002259
    Positive: Positive_clone: T07C4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene