WormBase Tree Display for Gene: WBGene00011064
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| WBGene00011064 | SMap | S_parent | Sequence | R06C7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | adsl-1 | Person_evidence | WBPerson10610 | |||||
| Sequence_name | R06C7.5 | ||||||||
| Molecular_name | R06C7.5a | ||||||||
| R06C7.5a.1 | |||||||||
| CE06248 | |||||||||
| R06C7.5b | |||||||||
| CE32476 | |||||||||
| R06C7.5b.1 | |||||||||
| Other_name | CELE_R06C7.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | adsl-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 11 Jul 2014 14:45:03 | WBPerson2970 | Name_change | CGC_name | adsl-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | adsl | ||||||||
| Allele (17) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Contained_in_operon | CEOP1380 | ||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00001503 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | The R06C7.5 gene encodes an ortholog of the human gene ADSL, which when mutated leads to adenylosuccinate lyase deficiency (OMIM:103050). | Paper_evidence | WBPaper00004637 | |||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in 'de novo' AMP biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency; breast cancer; and prostate cancer. Is an ortholog of human ADSL (adenylosuccinate lyase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050762 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:291) | ||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:291) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:291) | ||||||
| Molecular_info | Corresponding_CDS | R06C7.5a | |||||||
| R06C7.5b | |||||||||
| Corresponding_CDS_history | R06C7.5:wp90 | ||||||||
| Corresponding_transcript | R06C7.5a.1 | ||||||||
| R06C7.5b.1 | |||||||||
| Other_sequence (67) | |||||||||
| Associated_feature | WBsf219713 | ||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr1012902 | ||||||||
| Expr1034859 | |||||||||
| Expr1155077 | |||||||||
| Expr2009242 | |||||||||
| Expr2027479 | |||||||||
| Drives_construct | WBCnstr00030961 | ||||||||
| Construct_product | WBCnstr00030961 | ||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (133) | |||||||||
| Interaction (89) | |||||||||
| Map_info | Map | I | Position | 1.85739 | |||||
| Positive | Positive_clone | R06C7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
