Enriched in intestine and rectal gland cell based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including skn-1; hsf-1; and pgl-1 based on microarray and RNA-seq studies. Is affected by six chemicals including stavudine; Zidovudine; and paraquat based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: RSD-2 N-terminal domain and RSD-2, N-terminal.