WormBase Tree Display for Gene: WBGene00009992
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| WBGene00009992 | SMap | S_parent | Sequence | F53F4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | nduv-2 | Person_evidence | WBPerson555 | |||||
| Sequence_name | F53F4.10 | ||||||||
| Molecular_name | F53F4.10 | ||||||||
| F53F4.10.1 | |||||||||
| CE10972 | |||||||||
| Other_name | CELE_F53F4.10 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | nduv-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 16 Jan 2023 18:37:21 | WBPerson51134 | Name_change | CGC_name | nduv-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nduv | ||||||||
| Allele (16) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP5392 | ||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | F53F4.10 is orthologous to the human gene NADH-ubiquinone oxidoreductase flavoprotein 2 (NDUFV2; complex I of the respiratory chain); F53F4.10 protein is predicted to be mitochondrial. | Paper_evidence | WBPaper00004424 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable 2 iron, 2 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Is an ortholog of human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:700 | Homo sapiens | Paper_evidence | WBPaper00057247 | ||||
| WBPaper00064182 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 11 Oct 2022 00:00:00 | ||||||||
| Potential_model | DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7717) | |||||
| DOID:0112092 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7717) | ||||||
| Disease_relevance | Mutations in the human gene NADH-ubiquinone oxidoreductase flavoprotein 2 (NDUFV2; complex I of the respiratory chain), orthologous to the elegans gene, F53F4.10, have been associated with Mitochondrial complex I deficiency. | Homo sapiens | Accession_evidence | OMIM | 252010 | ||||
| 600532 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 23 Jul 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000212 | ||||||||
| WBDOannot00001332 | |||||||||
| WBDOannot00001336 | |||||||||
| Molecular_info | Corresponding_CDS | F53F4.10 | |||||||
| Corresponding_transcript | F53F4.10.1 | ||||||||
| Other_sequence (100) | |||||||||
| Associated_feature | WBsf653329 | ||||||||
| WBsf234836 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr1020378 | ||||||||
| Expr1034355 | |||||||||
| Expr1151956 | |||||||||
| Expr2004071 | |||||||||
| Expr2022295 | |||||||||
| Drives_construct | WBCnstr00031758 | ||||||||
| Construct_product | WBCnstr00031758 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (104) | |||||||||
| Interaction (134) | |||||||||
| Map_info | Map | V | Position | 5.53506 | |||||
| Positive | Positive_clone | F53F4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005928 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064182 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
