WormBase Tree Display for Gene: WBGene00009882
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| WBGene00009882 | SMap | S_parent | Sequence | F49C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | vha-17 | |||||||
| Sequence_name | F49C12.13 | ||||||||
| Molecular_name | F49C12.13 | ||||||||
| F49C12.13.1 | |||||||||
| CE37521 | |||||||||
| Other_name | fus-1 | Paper_evidence | WBPaper00026591 | ||||||
| Person_evidence | WBPerson539 | ||||||||
| WBPerson4071 | |||||||||
| CELE_F49C12.13 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | vha-17 | ||||||||
| DB_info | Database | AceView | gene | 4K87 | |||||
| WormQTL | gene | WBGene00009882 | |||||||
| WormFlux | gene | WBGene00009882 | |||||||
| NDB | locus_tag | CELE_F49C12.13 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00009882|UniProtKB=Q20591 | |||||||
| family | PTHR12263 | ||||||||
| NCBI | gene | 177757 | |||||||
| RefSeq | protein | NM_069235.10 | |||||||
| SwissProt | UniProtAcc | Q20591 | |||||||
| TREEFAM | TREEFAM_ID | TF300290 | |||||||
| UniProt_GCRP | UniProtAcc | Q20591 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 05 Jul 2004 16:15:45 | WBPerson1971 | Name_change | CGC_name | vha-17 | ||||
| 3 | 12 Jan 2006 15:59:17 | WBPerson2970 | Event | Acquires_merge | WBGene00001504 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vha | ||||||||
| Allele | WBVar00275112 | ||||||||
| WBVar00431974 | |||||||||
| WBVar01500079 | |||||||||
| WBVar01498996 | |||||||||
| WBVar00931288 | |||||||||
| WBVar00931289 | |||||||||
| WBVar01498928 | |||||||||
| WBVar01500245 | |||||||||
| Strain | WBStrain00022762 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (44) | |||||||||
| Structured_description | Concise_description | vha-17 (aka 'fus-1') encodes an an ortholog of subunit e of themembrane-bound (V0) domain of vacuolar proton-translocating ATPase(V-ATPase); VHA-17, like VHA-1 and VHA-12, antagonizes EFF-1-mediatedcell fusion in hypodermal cells; VHA-17 is expressed in gut cells ofcomma stage embryos, and in excretory cell and apical membranes of gutcells at later embryonic stages; VHA-17 is found in gut granules (a typeof lysosome, expected to require acidification), and glo-1 mutantintestines fail to show punctate VHA-17; VHA-17 is required forviability, but this is at least somewhat genetically separable fromVHA-17's antifusogenic activity. | Paper_evidence | WBPaper00025094 | |||||
| WBPaper00026591 | |||||||||
| WBPaper00026649 | |||||||||
| WBPaper00028773 | |||||||||
| WBPaper00028774 | |||||||||
| WBPaper00028775 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 19 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development; embryonic body morphogenesis; and regulation of syncytium formation by plasma membrane fusion. Located in apical junction complex and apical plasma membrane. Expressed in excretory cell; hypodermal cell; and intestine. Is an ortholog of human ATP6V0E2 (ATPase H+ transporting V0 subunit e2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F49C12.13 | |||||||
| Corresponding_CDS_history | F49C12.13:wp132 | ||||||||
| Corresponding_transcript | F49C12.13.1 | ||||||||
| Other_sequence (61) | |||||||||
| Associated_feature | WBsf655040 | ||||||||
| WBsf655041 | |||||||||
| WBsf228811 | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern | Expr3750 | ||||||||
| Expr1024362 | |||||||||
| Expr1034309 | |||||||||
| Expr1151634 | |||||||||
| Expr2017983 | |||||||||
| Expr2036119 | |||||||||
| Drives_construct | WBCnstr00031847 | ||||||||
| Construct_product | WBCnstr00031847 | ||||||||
| Antibody | WBAntibody00000847 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction | WBInteraction000004840 | ||||||||
| WBInteraction000299408 | |||||||||
| WBInteraction000502754 | |||||||||
| WBInteraction000521887 | |||||||||
| Map_info | Map | IV | Position | 4.16956 | Error | 0.004099 | |||
| Positive | Positive_clone | F49C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5673 | |||||||
| 5411 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
