WormBase Tree Display for Gene: WBGene00009674
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| WBGene00009674 | SMap | S_parent | Sequence | F44A6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | nucb-1 | Person_evidence | WBPerson1519 | |||||
| WBPerson490 | |||||||||
| Sequence_name | F44A6.1 | ||||||||
| Molecular_name | F44A6.1a | ||||||||
| F44A6.1a.1 | |||||||||
| CE03322 | |||||||||
| F44A6.1b | |||||||||
| CE31514 | |||||||||
| F44A6.1b.1 | |||||||||
| Other_name | CELE_F44A6.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | nucb-1 | ||||||||
| DB_info | Database | AceView | gene | XK817 | |||||
| WormQTL | gene | WBGene00009674 | |||||||
| WormFlux | gene | WBGene00009674 | |||||||
| NDB | locus_tag | CELE_F44A6.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00009674|UniProtKB=Q8MQ51 | |||||||
| family | PTHR19237 | ||||||||
| NCBI | gene | 181230 | |||||||
| RefSeq | protein | NM_171970.8 | |||||||
| NM_171763.5 | |||||||||
| TREEFAM | TREEFAM_ID | TF323218 | |||||||
| TrEMBL | UniProtAcc | Q8MQ51 | |||||||
| Q20384 | |||||||||
| UniProt_GCRP | UniProtAcc | Q8MQ51 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 04 Mar 2005 10:23:45 | WBPerson2970 | Name_change | CGC_name | nucb-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nucb | ||||||||
| Allele (46) | |||||||||
| Strain | WBStrain00003372 | ||||||||
| WBStrain00029028 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00068003 | ||||||||
| 00068004 | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | F44A6.1 encodes two isoforms of a nucleobindin homolog that each contain a calcium-binding EF-hand domain and a glutamine/asparagine-rich domain; F44A6.1 is expressed in muscle (pharyngeal, body wall, and vulval), with weak expression in head and tail neurons and in (mainly posterior) intestinal cells; F44A6.1 has no obvious function in vivo, since it has no obvious phenotype when deleted or inactivated by RNAi (whether in a normal genetic background, or in goa-1 and egl-30 mutant backgrounds). | Paper_evidence | WBPaper00005068 | |||||
| WBPaper00006194 | |||||||||
| WBPaper00012788 | |||||||||
| WBPaper00012830 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable calcium ion binding activity. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment. Expressed in body wall musculature; intestinal cell; neurons; and non-striated muscle. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human NUCB1 (nucleobindin 1) and NUCB2 (nucleobindin 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8044) | ||||
| Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, the heat-shock transcription factor, after activation, induces the expression of other small heat shock proteins (sHSP); HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes; also, the sHSPs, HSP-16.1, HSP-16.41 and DNJ-19 are required for an acquired tolerance to heat stroke. | Homo sapiens | Paper_evidence | WBPaper00041564 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 May 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F44A6.1a | |||||||
| F44A6.1b | |||||||||
| Corresponding_CDS_history | F44A6.1:wp83 | ||||||||
| Corresponding_transcript | F44A6.1a.1 | ||||||||
| F44A6.1b.1 | |||||||||
| Other_sequence (58) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00032213 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00047240 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063367 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063379 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1018 | ||||||||
| Expr2754 | |||||||||
| Expr1028331 | |||||||||
| Expr1034230 | |||||||||
| Expr1151098 | |||||||||
| Expr2014523 | |||||||||
| Expr2032762 | |||||||||
| Drives_construct | WBCnstr00003843 | ||||||||
| WBCnstr00010934 | |||||||||
| WBCnstr00032004 | |||||||||
| Construct_product | WBCnstr00010934 | ||||||||
| WBCnstr00032004 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (133) | |||||||||
| Interaction (11) | |||||||||
| Map_info | Map | X | Position | 1.87445 | Error | 0.002694 | |||
| Positive | Positive_clone | F44A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5176 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00026830 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
