WormBase Tree Display for Gene: WBGene00009372
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| WBGene00009372 | SMap | S_parent | Sequence | F34D10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | evl-18 | Person_evidence | WBPerson220 | |||||
| Sequence_name | F34D10.2 | ||||||||
| Molecular_name | F34D10.2 | ||||||||
| F34D10.2.1 | |||||||||
| CE41399 | |||||||||
| Other_name | cdc-45 | Person_evidence | WBPerson171 | ||||||
| CELE_F34D10.2 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | evl-18 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 16 Jul 2007 10:16:17 | WBPerson1983 | Event | Split_into | WBGene00045484 | ||||
| 3 | 30 Aug 2012 13:10:47 | WBPerson2970 | Event | Acquires_merge | WBGene00001356 | ||||
| Name_change | CGC_name | evl-18 | |||||||
| Other_name | cdc-45 | ||||||||
| Acquires_merge | WBGene00001356 | ||||||||
| Split_into | WBGene00045484 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | evl | ||||||||
| Allele (68) | |||||||||
| Legacy_information | [C.elegansII] ar117 : everted vulva, sterile; no L4 vulval invagination; abnormal uterus; distal germline abnormal, no sperm or oocytes. NA1. [Seydoux et al., 1993] | ||||||||
| Strain | WBStrain00008015 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Automated_description | Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Located in nucleus. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Is an ortholog of human CDC45 (cell division cycle 45). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:0080518 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1739) | |||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including CDC45; C. elegans CDC45/evl-18 is involved in DNA replication initiation as RNAi depletion of evl-18 affects DNA replication and delays S phase; evl-18 knock-down phenotypes include reduced brood size, early embryo sister chromatid segregration defects, and sperm development and sterility defects; evl-18 provides a potential model system to study genes involved in 22q11.2DS. | Homo sapiens | Paper_evidence | WBPaper00047004 | |||||
| WBPaper00040279 | |||||||||
| WBPaper00047062 | |||||||||
| Accession_evidence | OMIM | 611867 | |||||||
| 603465 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 16 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000368 | ||||||||
| Molecular_info | Corresponding_CDS | F34D10.2 | |||||||
| Corresponding_CDS_history | F34D10.2:wp179 | ||||||||
| Corresponding_transcript | F34D10.2.1 | ||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf650927 | ||||||||
| WBsf666681 | |||||||||
| WBsf666682 | |||||||||
| WBsf991883 | |||||||||
| WBsf991884 | |||||||||
| WBsf226385 | |||||||||
| WBsf226386 | |||||||||
| WBsf226387 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr12321 | ||||||||
| Expr1012133 | |||||||||
| Expr1034106 | |||||||||
| Expr1150133 | |||||||||
| Expr2011388 | |||||||||
| Expr2029624 | |||||||||
| Drives_construct | WBCnstr00032243 | ||||||||
| Construct_product | WBCnstr00032243 | ||||||||
| Antibody | WBAntibody00002758 | ||||||||
| Microarray_results (13) | |||||||||
| Expression_cluster (94) | |||||||||
| Interaction (179) | |||||||||
| Map_info | Positive | Positive_clone | F34D10 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Mapping_data | Multi_point | 3473 | |||||||
| Interpolated_map_position | III | -4.30176 | |||||||
| Reference | WBPaper00001738 | ||||||||
| WBPaper00015476 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040279 | |||||||||
| WBPaper00044861 | |||||||||
| WBPaper00049197 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056327 | |||||||||
| WBPaper00065080 | |||||||||
| WBPaper00066002 | |||||||||
| Method | Gene |
