WormBase Tree Display for Gene: WBGene00008765
expand all nodes | collapse all nodes | view schema
| WBGene00008765 | SMap | S_parent | Sequence | F13G3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ttx-7 | Person_evidence | WBPerson433 | |||||
| Sequence_name | F13G3.5 | ||||||||
| Molecular_name | F13G3.5a | ||||||||
| F13G3.5a.1 | |||||||||
| CE47972 | |||||||||
| F13G3.5b | |||||||||
| CE48079 | |||||||||
| F13G3.5a.2 | |||||||||
| F13G3.5b.1 | |||||||||
| Other_name | CELE_F13G3.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | ttx-7 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 31 Jan 2007 13:58:31 | WBPerson2970 | Name_change | CGC_name | ttx-7 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ttx | ||||||||
| Allele (30) | |||||||||
| Strain | WBStrain00032133 | ||||||||
| WBStrain00032183 | |||||||||
| WBStrain00022002 | |||||||||
| WBStrain00022001 | |||||||||
| WBStrain00021999 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP1388 | ||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00012390 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00044063 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | ttx-7 encodes, by alternative splicing, two isoforms of a myo-inositolmonophosphatase (IMPase) required for normal thermotaxis and chemotaxisto sodium, as well as for subcellular localization of SNB-1 and SNG-1 inRIA interneurons; one isoform ('ttx-7a') has much higher transgenicrescuing activity of ttx-7(nj40) than the other ('ttx-7b'), so ttx-7a isconsidered the major isoform in vivo; a rescuing translational fusion ofTTX-7 to EGFP is strongly expressed in coelomocytes and a few head andtail neurons, with weaker expression in motor neurons, intestine, andsomatic gonad; TTX-7::EGFP is cytoplasmic, and can rescue mutantphenotypes when transiently expressed in adults; TTX-7 proteins areorthologous to human IMPA1 (OMIM:602064) and IMPA2 (OMIM:605922),possible mediators of manic depressive psychosis; ttx-7 mutationsdisplay ahtermic and chemotactic phenotypes, partially suppress thethermophilic phenotype of tax-6 mutations, and cause mislocalization ofSNB-1 and SNG-1; while ttx-7 expression is required in RIA to rescuethermotaxis phenotypes, RIA in ttx-7 mutants is morphologically normal;ttx-7 mutant phenotypes can be rescued by exogenous inositol applied toadults; ttx-7 mutations can be phenocopied in wild-type worms by lithiumtreatment of adults, and this phenocopy can be suppressed byoverexpression of a ttx-7 transgene, or by exogenous inositol orsorbitol; ttx-7 mutant development is delayed by exogenous galactose,implying a link between TTX-7/IMPase and galactose metabolism. | Paper_evidence | WBPaper00028886 | |||||
| WBPaper00029230 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 04 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in chemotaxis; protein localization to synapse; and thermotaxis. Located in cytoplasm. Expressed in several structures, including coelomocyte; gonad; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59; bipolar disorder; and schizophrenia. Is an ortholog of human IMPA1 (inositol monophosphatase 1) and IMPA2 (inositol monophosphatase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6051) | ||||
| DOID:0081221 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6050) | ||||||
| DOID:1059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6050) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6051) | ||||||
| Molecular_info | Corresponding_CDS | F13G3.5a | |||||||
| F13G3.5b | |||||||||
| Corresponding_CDS_history | F13G3.5:wp68 | ||||||||
| F13G3.5a:wp176 | |||||||||
| F13G3.5b:wp176 | |||||||||
| Corresponding_transcript | F13G3.5a.1 | ||||||||
| F13G3.5a.2 | |||||||||
| F13G3.5b.1 | |||||||||
| Other_sequence (66) | |||||||||
| Associated_feature | WBsf649306 | ||||||||
| WBsf663810 | |||||||||
| WBsf664431 | |||||||||
| WBsf976775 | |||||||||
| WBsf976776 | |||||||||
| WBsf976777 | |||||||||
| WBsf976778 | |||||||||
| WBsf219736 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00003372 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00044539 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116918 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030906 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3894 | ||||||||
| Expr4403 | |||||||||
| Expr1027404 | |||||||||
| Expr1033823 | |||||||||
| Expr1148493 | |||||||||
| Expr2017630 | |||||||||
| Expr2035770 | |||||||||
| Drives_construct | WBCnstr00011726 | ||||||||
| WBCnstr00011971 | |||||||||
| WBCnstr00032706 | |||||||||
| Construct_product | WBCnstr00011971 | ||||||||
| WBCnstr00032706 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (116) | |||||||||
| Interaction (94) | |||||||||
| Map_info | Map | I | Position | 1.88331 | Error | 0.002966 | |||
| Positive | Positive_clone | F13G3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
