WormBase Tree Display for Gene: WBGene00007635
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| WBGene00007635 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | npr-4 | Paper_evidence | WBPaper00033064 | |||||
| Person_evidence | WBPerson2136 | ||||||||
| Sequence_name | C16D6.2 | ||||||||
| Molecular_name (14) | |||||||||
| Other_name | CELE_C16D6.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | npr-4 | ||||||||
| DB_info | Database | AceView | gene | XN154 | |||||
| WormQTL | gene | WBGene00007635 | |||||||
| WormFlux | gene | WBGene00007635 | |||||||
| NDB | locus_tag | CELE_C16D6.2 | |||||||
| Panther | gene | CAEEL|WormBase=C16D6.2b|UniProtKB=A0A0K3AYF5 | |||||||
| family | PTHR45695 | ||||||||
| NCBI | gene | 182684 | |||||||
| RefSeq | protein | NM_001313375.3 | |||||||
| NM_001307873.3 | |||||||||
| NM_077700.7 | |||||||||
| NM_001307874.4 | |||||||||
| TrEMBL | UniProtAcc | A0A0K3AYF5 | |||||||
| A0A078BS36 | |||||||||
| A0A078BTK0 | |||||||||
| O62062 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A0K3AYF5 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 20 Dec 2011 16:46:04 | WBPerson2970 | Name_change | CGC_name | npr-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | npr | ||||||||
| Allele (213) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (34) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Automated_description | Predicted to enable G protein-coupled receptor activity. Involved in regulation of muscle contraction. Predicted to be located in membrane. Expressed in several structures, including PQR; coelomocyte; interneuron; nerve ring; and rectal gland cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in hypertension. Is an ortholog of human PRLHR (prolactin releasing hormone receptor). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00041253 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Nov 2013 00:00:00 | ||||||||
| Potential_model | DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4464) | |||||
| Disease_relevance | In elegans, alpha-synuclein (alpha-syn) toxicity, implicated in Parkinson''s disease and other synucleinopathies, is modeled by expressing it from the dopamine transporter (dat-1) gene promotor in transgenic GFP worms, resulting in an age-dependent progressive loss of dopaminergic neurons; using this system, it was seen that the knock-down of specific candidate genes in elegans, that interact with catp-6/ATP13A2, resulted in significant enhancement of alpha-syn-induced dopaminergic neurodegeneration; these catp-6/ATP13A2 interactors include the elegans ortholog of neuropeptide Y receptor Y1 (npr-4), AP2 associated kinase 1 (AAK1; sel-5), coagulation factor II (thrombin) receptor (dop-2 and npr-24), histone deacetylase 6 (hda-6), and YIP1 interacting factor homolog A (yif-1). | Homo sapiens | Paper_evidence | WBPaper00041253 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Nov 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000246 | ||||||||
| Molecular_info | Corresponding_CDS | C16D6.2a | |||||||
| C16D6.2b | |||||||||
| C16D6.2c | |||||||||
| C16D6.2d | |||||||||
| Corresponding_CDS_history | C16D6.2:wp131 | ||||||||
| Corresponding_transcript | C16D6.2a.1 | ||||||||
| C16D6.2b.1 | |||||||||
| C16D6.2b.2 | |||||||||
| C16D6.2c.1 | |||||||||
| C16D6.2c.2 | |||||||||
| C16D6.2d.1 | |||||||||
| Other_sequence | MI03769 | ||||||||
| AI438264.1 | |||||||||
| JI171599.1 | |||||||||
| MI01326 | |||||||||
| MIC00702_1 | |||||||||
| AY882441.1 | |||||||||
| OVC02861_1 | |||||||||
| Associated_feature (23) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00028971 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00010863 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040729 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075424 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8975 | ||||||||
| Expr12804 | |||||||||
| Expr1013004 | |||||||||
| Expr1144774 | |||||||||
| Expr2014424 | |||||||||
| Expr2032665 | |||||||||
| Drives_construct | WBCnstr00013648 | ||||||||
| WBCnstr00018592 | |||||||||
| WBCnstr00022791 | |||||||||
| WBCnstr00033589 | |||||||||
| Construct_product | WBCnstr00022791 | ||||||||
| WBCnstr00033589 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (125) | |||||||||
| Interaction (27) | |||||||||
| Map_info | Map | X | Position | 7.17548 | |||||
| Positive | Positive_clone | C16D6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
