WormBase Tree Display for Gene: WBGene00006952
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| WBGene00006952 | SMap | S_parent | Sequence | ZK377 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | wrt-6 | Person_evidence | WBPerson83 | |||||
| Sequence_name | ZK377.1 | ||||||||
| Molecular_name | ZK377.1 | ||||||||
| ZK377.1.1 | |||||||||
| CE37175 | |||||||||
| Other_name | ZK377 | Paper_evidence | WBPaper00002823 | ||||||
| CELE_ZK377.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | wrt-6 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | wrt | ||||||||
| Allele (39) | |||||||||
| Possibly_affected_by | WBVar02157903 | ||||||||
| Strain | WBStrain00047061 | ||||||||
| WBStrain00052695 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (46) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | wrt-6 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Wart domain, an short region of low-complexitysequence, and a Hint/Hog domain; WRT-6 is expressed in sheath and socketcells of anterior sensilla, seam cells, and hypodermis; the Hint/Hogdomain is predicted to cut WRT-6 into two halves and then covalentlylink cholesterol to the C-terminus of the Wart domain; the Wart domainis predicted to form a cysteine-crosslinked protein involved inintercellular signalling, and it has subtle similarity to the N-terminalHedge domain of HEDGEHOG proteins; WRT-6 is weakly required for normalmolting; WRT-6 is also required for normal growth to full size andlocomotion; all of these requirements may reflect common defects incholesterol-dependent hedgehog-like signalling or in vesicletrafficking. | Paper_evidence | WBPaper00003717 | |||||
| WBPaper00026841 | |||||||||
| WBPaper00027263 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 05 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable peptidase activity. Predicted to be involved in cell-cell signaling; protein autoprocessing; and system development. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in anterior ganglion (ant); hypodermis; and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; gastrointestinal system cancer (multiple); and glomerulonephritis (multiple). Is an ortholog of human SHH (sonic hedgehog signaling molecule). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (22) | ||||||||
| Molecular_info | Corresponding_CDS | ZK377.1 | |||||||
| Corresponding_CDS_history | ZK377.1:wp128 | ||||||||
| Corresponding_transcript | ZK377.1.1 | ||||||||
| Other_sequence | Tcol_isotig15559 | ||||||||
| JI171270.1 | |||||||||
| Name_isotig06845 | |||||||||
| MI05621 | |||||||||
| GR15773 | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00077012 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00038276 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021983 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076985 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089220 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059384 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr646 | ||||||||
| Expr1026678 | |||||||||
| Expr1032964 | |||||||||
| Expr1162811 | |||||||||
| Expr2018081 | |||||||||
| Expr2036219 | |||||||||
| Drives_construct | WBCnstr00008615 | ||||||||
| WBCnstr00012471 | |||||||||
| WBCnstr00034076 | |||||||||
| Construct_product | WBCnstr00034076 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (278) | |||||||||
| Interaction (139) | |||||||||
| WBProcess | WBbiopr:00000123 | ||||||||
| Map_info | Map | X | Position | -10.3063 | Error | 0.01522 | |||
| Positive | Positive_clone | ZK377 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4357 | |||||||
| 4758 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
