WormBase Tree Display for Gene: WBGene00006950
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| WBGene00006950 | Evidence | Paper_evidence | WBPaper00003717 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | ZK678 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | wrt-4 | Person_evidence | WBPerson83 | |||||
| Sequence_name | ZK678.5 | ||||||||
| Molecular_name | ZK678.5 | ||||||||
| ZK678.5.1 | |||||||||
| CE24735 | |||||||||
| Other_name | ZK678 | Paper_evidence | WBPaper00002823 | ||||||
| CELE_ZK678.5 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | wrt-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | wrt | ||||||||
| Allele (95) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | wrt-4 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Wart domain, an short region of low-complexitysequence, and a Hint/Hog domain; WRT-4 is expressed strongly inhypodermal syncytia hyp6-hyp10 from 3-fold embryos to adults; theHint/Hog domain is predicted to cut WRT-4 into two halves and thencovalently link cholesterol to the C-terminus of the Wart domain; theWart domain is predicted to form a cysteine-crosslinked protein involvedin intercellular signalling, and it has subtle similarity to theN-terminal Hedge domain of HEDGEHOG proteins; WRT-4 is weakly requiredfor normal molting; WRT-4 is also required for normal adult alaeformation, growth to full size, locomotion, and male tail development;all of these requirements may reflect common defects incholesterol-dependent hedgehog-like signalling or in vesicletrafficking. | Paper_evidence | WBPaper00003717 | |||||
| WBPaper00026841 | |||||||||
| WBPaper00027263 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 05 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable peptidase activity. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in hyp10; hyp6; hyp7 syncytium; hyp8; and hyp9. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; gastrointestinal system cancer (multiple); and glomerulonephritis (multiple). Is an ortholog of human SHH (sonic hedgehog signaling molecule). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (22) | ||||||||
| Molecular_info | Corresponding_CDS | ZK678.5 | |||||||
| Corresponding_transcript | ZK678.5.1 | ||||||||
| Other_sequence | CR07553 | ||||||||
| CRC07527_1 | |||||||||
| Associated_feature | WBsf654671 | ||||||||
| WBsf671393 | |||||||||
| WBsf671394 | |||||||||
| WBsf671395 | |||||||||
| WBsf1008328 | |||||||||
| WBsf238350 | |||||||||
| WBsf238351 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00022124 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00089223 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001249 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076983 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027686 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076976 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059657 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077010 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr644 | ||||||||
| Expr1011469 | |||||||||
| Expr1032963 | |||||||||
| Expr1163068 | |||||||||
| Expr2018079 | |||||||||
| Expr2036217 | |||||||||
| Drives_construct | WBCnstr00012469 | ||||||||
| WBCnstr00034078 | |||||||||
| Construct_product | WBCnstr00034078 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (266) | |||||||||
| Interaction (183) | |||||||||
| WBProcess | WBbiopr:00000123 | ||||||||
| Map_info | Map | X | Position | 22.9576 | Error | 0.001831 | |||
| Positive | Positive_clone | ZK678 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5265 | |||||||
| 5356 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | cm02c8, yk175d1 yk105d8 cDNAs removed from sequence list above now canonical one added. sdm 11/00 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
