WormBase Tree Display for Gene: WBGene00006917
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WBGene00006917 | SMap | S_parent | Sequence | C17H12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | vha-8 | |||||||
Sequence_name | C17H12.14 | ||||||||
Molecular_name | C17H12.14 | ||||||||
C17H12.14.1 | |||||||||
CE19362 | |||||||||
Other_name | pes-6 | CGC_data_submission | |||||||
CELE_C17H12.14 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | vha-8 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | vha | ||||||||
Allele (16) | |||||||||
Legacy_information | [C.elegansII] NMK. pes-6:lacZ expressed throughout H-shaped excretory cell, also in nuclei of lateral hypodermis. Clone UL#64A1, YAC 55E1. [Young and Hope 1993; UL] | ||||||||
Strain | WBStrain00029316 | ||||||||
WBStrain00029318 | |||||||||
WBStrain00035242 | |||||||||
WBStrain00023532 | |||||||||
WBStrain00051766 | |||||||||
WBStrain00051767 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (13) | |||||||||
Ortholog (45) | |||||||||
Structured_description | Concise_description | vha-8 encodes an ortholog of subunit E of the cytoplasmic (V1) domain ofvacuolar proton-translocating ATPase (V-ATPase); VHA-8 is a predictedcytosolic stator (stalk) component; VHA-8 is required for embryonic andlarval viability, for ovulation, and for receptor-mediated endocytosisof yolk protein; VHA-8 is highly expressed in the cytoplasm of excretorycanals throughout development, and in the stacked apical plasma membranesheets of syncytial hypodermal cells; general levels of VHA-8 proteinare very low in embryos but increase strongly after hatching; vha-8mutants show necrotic cell death in hypodermis and intestine,paralleling the role of VHA-12 and other V-ATPase subunits in neuronalnecrosis; VHA-8 is dispensable for alae formation, like the V1 subunitVHA-13, but not like the V0 subunits VHA-1 and VHA-4. | Paper_evidence | WBPaper00006007 | |||||
WBPaper00026640 | |||||||||
WBPaper00027625 | |||||||||
WBPaper00027697 | |||||||||
WBPaper00028360 | |||||||||
WBPaper00028773 | |||||||||
WBPaper00028774 | |||||||||
WBPaper00028775 | |||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 19 Nov 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Located in apical plasma membrane and cytoplasm. Expressed in head; hypodermis; and intestine. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Is an ortholog of human ATP6V1E2 (ATPase H+ transporting V1 subunit E2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0070140 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:857) | ||||
Molecular_info | Corresponding_CDS | C17H12.14 | |||||||
Corresponding_transcript | C17H12.14.1 | ||||||||
Other_sequence (141) | |||||||||
Associated_feature | WBsf646042 | ||||||||
WBsf981775 | |||||||||
WBsf996837 | |||||||||
WBsf228454 | |||||||||
WBsf228455 | |||||||||
WBsf228456 | |||||||||
WBsf228457 | |||||||||
WBsf228458 | |||||||||
Experimental_info | RNAi_result (35) | ||||||||
Expr_pattern (13) | |||||||||
Drives_construct | WBCnstr00000144 | ||||||||
WBCnstr00002097 | |||||||||
WBCnstr00004220 | |||||||||
WBCnstr00010876 | |||||||||
WBCnstr00011962 | |||||||||
WBCnstr00038089 | |||||||||
Construct_product | WBCnstr00011962 | ||||||||
Antibody | WBAntibody00000656 | ||||||||
WBAntibody00001091 | |||||||||
Microarray_results (17) | |||||||||
Expression_cluster (146) | |||||||||
Interaction (111) | |||||||||
Map_info | Map | IV | Position | 3.23455 | Error | 0.001195 | |||
Positive | Positive_clone | C17H12 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | Multi_point | 4752 | |||||||
5424 | |||||||||
Pseudo_map_position | |||||||||
Reference (25) | |||||||||
Remark | pes-6 was incorrectly connected to C17H12.4 [030416 ck1] | ||||||||
The pes-6 was merged with vha-8 following advice from the CGC. pes-6 is now an other name of vha-8 [krb 030512] | |||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |