WormBase Tree Display for Gene: WBGene00006870
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| WBGene00006870 | SMap | S_parent | Sequence | F14F3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | vab-3 | Person_evidence | WBPerson77 | |||||
| Sequence_name | F14F3.1 | ||||||||
| Molecular_name | F14F3.1a | ||||||||
| F14F3.1a.1 | |||||||||
| CE24899 | |||||||||
| F14F3.1b | |||||||||
| CE28216 | |||||||||
| F14F3.1c | |||||||||
| CE28217 | |||||||||
| F14F3.1a.2 | |||||||||
| F14F3.1b.1 | |||||||||
| F14F3.1c.1 | |||||||||
| Other_name | lin-20 | ||||||||
| mab-18 | CGC_data_submission | ||||||||
| pax-6 | |||||||||
| sax-4 | Paper_evidence | WBPaper00003665 | |||||||
| CELE_F14F3.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | vab-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 08 Oct 2013 00:00:00 | WBPerson2970 | Name_change | Other_name | sax-4 | ||||
| Status | Live | ||||||||
| Gene_info (12) | |||||||||
| Disease_info | Potential_model (14) | ||||||||
| Disease_relevance | The human ortholog, PAX6 (Paired box gene 6), is mutated in several developmental disorders that include disorders of eye development, like Aniridia, Coloboma, Gillespie syndrome, Keratitis, Peters anamaly and Optic nerve hypoplasia; PAX6 proteins are highly conserved, contain a paired domain (PD) and the homeodomain (HD), which are DNA binding domains and are involved in brain and eye development in many species as regulators of transcription; in C. elegans, the pax-6 gene encodes several isoforms, mutant studies of which, indicate that paired-domain (PD) containing isoforms are involved in epidermal morphogenesis, epidermal cell fates, and gonad cell migration; mutations in non-PD isoforms affect the fate of sensory structures in the mail tale; further, PAX-6 isoforms can have an additive, synergistic or antagonistic interaction depending on cellular context. | Homo sapiens | Paper_evidence | WBPaper00024640 | |||||
| Accession_evidence | OMIM | 604219 | |||||||
| 120430 | |||||||||
| 120200 | |||||||||
| 136520 | |||||||||
| 206700 | |||||||||
| 148190 | |||||||||
| 165550 | |||||||||
| 60422 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 May 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F14F3.1a | |||||||
| F14F3.1b | |||||||||
| F14F3.1c | |||||||||
| Corresponding_CDS_history | F14F3.1:wp47 | ||||||||
| Corresponding_transcript | F14F3.1a.1 | ||||||||
| F14F3.1a.2 | |||||||||
| F14F3.1b.1 | |||||||||
| F14F3.1c.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature (38) | |||||||||
| Gene_product_binds | WBsf027927 | ||||||||
| WBsf977965 | |||||||||
| Transcription_factor | WBTranscriptionFactor000105 | ||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern (21) | |||||||||
| Drives_construct (16) | |||||||||
| Construct_product | WBCnstr00000175 | ||||||||
| WBCnstr00000176 | |||||||||
| WBCnstr00018671 | |||||||||
| WBCnstr00018672 | |||||||||
| WBCnstr00018673 | |||||||||
| WBCnstr00034118 | |||||||||
| Antibody | WBAntibody00000202 | ||||||||
| WBAntibody00000203 | |||||||||
| WBAntibody00001432 | |||||||||
| Microarray_results (38) | |||||||||
| Expression_cluster (178) | |||||||||
| Interaction (458) | |||||||||
| Anatomy_function | WBbtf0613 | ||||||||
| Map_info | Map | X | Position | 2.22417 | Error | 0.001647 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C33D3 | |||||||
| C56D7 | |||||||||
| CB11 | |||||||||
| F14F3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| M4B | |||||||||
| Negative | Negative_clone | AF4 | |||||||
| C12H7 | |||||||||
| C29G11 | |||||||||
| C39B10 | |||||||||
| K08A5 | |||||||||
| ZC504 | |||||||||
| Mapping_data | 2_point (12) | ||||||||
| Multi_point (26) | |||||||||
| Pos_neg_data (14) | |||||||||
| Landmark_gene | |||||||||
| Reference (127) | |||||||||
| Remark | vab-3 only corresponds to F14F3.1a whereas mab-18 corresponds to the splice variants F14F3.1b and F14F3.1c | ||||||||
| mab-18 corresponds only to F14F3.1b and F14F3.1c. The first splice variant (F14F3.1a) corresponds to the vab-3 gene. | |||||||||
| Method | Gene |
