WormBase Tree Display for Gene: WBGene00006788

WBGene00006788 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: unc-53 Person_evidence: WBPerson261
      Sequence_name: F45E10.1
      Molecular_name (24)
      Other_name: CELE_F45E10.1 Accession_evidence: NDB BX284602
      Public_name: unc-53
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143183
    Allele (424)
    Legacy_information: e404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569).
      See also e2432, e2499, n152, n166, n569
      [C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG]
    Strain: WBStrain00026706
      WBStrain00026870
      WBStrain00032757
      WBStrain00034470
      WBStrain00034483
      WBStrain00037045
      WBStrain00004162
      WBStrain00004572
      WBStrain00005655
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (46)
    Structured_description (2)
  Disease_info: Potential_model: DOID:2559 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:15998)
  Molecular_info: Corresponding_CDS: F45E10.1a
      F45E10.1b
      F45E10.1c
      F45E10.1d
      F45E10.1e
      F45E10.1f
      F45E10.1g
      F45E10.1h
    Corresponding_CDS_history: F45E10.1:wp82
    Corresponding_transcript: F45E10.1a.1
      F45E10.1b.1
      F45E10.1c.1
      F45E10.1d.1
      F45E10.1e.1
      F45E10.1f.1
      F45E10.1g.1
      F45E10.1h.1
    Other_sequence (27)
    Associated_feature (66)
  Experimental_info: RNAi_result (14)
    Expr_pattern (12)
    Drives_construct (25)
    Construct_product: WBCnstr00009444
      WBCnstr00010519
      WBCnstr00010520
      WBCnstr00010521
      WBCnstr00034150
    Antibody: WBAntibody00001615
      WBAntibody00001625
    Microarray_results: SMD_F45E10.1
      183518_s_at
      A_12_P119500
      Aff_F45E10.1
      GPL13394_WBGene00006788
      GPL13914_F45E10.1
      GPL14144_F45E10.1c_4568-4627_0.927_3_C
      GPL14144_F45E10.1c_4658-4717_0.932_2_B
      GPL14144_F45E10.1c_4864-4923_0.948_1_A
      GPL19516_CGZ0021849
      GPL19516_CGZ0021850
      GPL19516_CGZ0021851
      GPL19516_CGZ0021852
      GPL19516_CGZ0021853
      GPL19516_CGZ0021854
      GPL19516_CGZ0021855
      GPL19516_CGZ0021856
      GPL21109_F45E10.1a
      GPL3518_CE31346
      GPL8304_CE_WBGene00006788_A
      GPL8673_F45E10_1aP03499
      GPL8673_F45E10_1aP03772
      GPL8673_F45E10_1aP04276
      GPL8673_F45E10_1bP03397
      GPL8673_F45E10_1bP03670
      GPL8673_F45E10_1bP04174
      GPL8673_F45E10_1cP03712
      GPL8673_F45E10_1cP03985
      GPL8673_F45E10_1cP04489
      GPL8673_F45E10_1dP03310
      GPL8673_F45E10_1dP03583
      GPL8673_F45E10_1dP04087
      GPL8673_F45E10_1eP02452
      GPL8673_F45E10_1eP02725
      GPL8673_F45E10_1eP03229
      GPL9450_F45E10.1a
      GPL9450_F45E10.1b
      cea2.3.14445
      cea2.d.03469
      cea2.d.26268
    Expression_cluster (219)
    Interaction (103)
    Anatomy_function: WBbtf0113
      WBbtf0114
      WBbtf0118
      WBbtf0119
  Map_info: Map: II Position: 3.16568 Error: 0.005694
    Well_ordered
    Positive: Positive_clone: F45E10 Inferred_automatically: From sequence, transcript, pseudogene data
        T28D2
    Mapping_data: 2_point: 43
      Multi_point (11)
      Pos_neg_data: 2145
        2146
        2159
        2163
        4533
        4534
        4535
        4536
        4539
        10562
  Reference (99)
  Method: Gene