WormBase Tree Display for Gene: WBGene00006747
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| WBGene00006747 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | unc-7 | Person_evidence | WBPerson261 | |||||
| Sequence_name | R07D5.1 | ||||||||
| Molecular_name (31) | |||||||||
| Other_name | unc-12 | ||||||||
| unc-124 | Person_evidence | WBPerson621 | |||||||
| WBPerson579 | |||||||||
| CELE_R07D5.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | unc-7 | ||||||||
| DB_info | Database | AceView | gene | XP740 | |||||
| WormQTL | gene | WBGene00006747 | |||||||
| WormFlux | gene | WBGene00006747 | |||||||
| NDB | locus_tag | CELE_R07D5.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006747|UniProtKB=Q03412 | |||||||
| family | PTHR11893 | ||||||||
| NCBI | gene | 181608 | |||||||
| RefSeq | protein | NM_001350352.4 | |||||||
| NM_001350353.4 | |||||||||
| NM_001270327.3 | |||||||||
| NM_001350355.3 | |||||||||
| NM_001350356.3 | |||||||||
| NM_001350358.3 | |||||||||
| NM_001350354.3 | |||||||||
| NM_001392896.1 | |||||||||
| NM_001270326.3 | |||||||||
| NM_001350357.3 | |||||||||
| SwissProt | UniProtAcc | Q03412 | |||||||
| TrEMBL | UniProtAcc | A0A1T5HUM5 | |||||||
| C8JQR8 | |||||||||
| A0A1T5HUM9 | |||||||||
| A0A1T5HUM1 | |||||||||
| A0A1T5HUM6 | |||||||||
| A0A1T5HUM7 | |||||||||
| A0A1T5HUM3 | |||||||||
| C8JQR7 | |||||||||
| A0A1T5HUN4 | |||||||||
| UniProt_GCRP | UniProtAcc | Q03412 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 23 Aug 2005 13:14:37 | WBPerson2970 | Event | Acquires_merge | WBGene00006847 | ||||
| Name_change | Other_name | unc-124 | |||||||
| 3 | 03 Mar 2017 00:18:26 | WBPerson1983 | Event | Acquires_merge | WBGene00007526 | ||||
| Acquires_merge | WBGene00006847 | ||||||||
| WBGene00007526 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00142903 | ||||||||
| Allele (496) | |||||||||
| Legacy_information | e5 : moves backward better than forward kinker in forward movement active healthy slightly thin. ES3 ME0. NA5 (e42 e65 (pka unc-12) etc.). | ||||||||
| See unc-7. | |||||||||
| See also e65 | |||||||||
| [C.elegansII] e5 : moves backward better than forward, kinker in forward movement, active, healthy, slightly thin. Suppresses anaesthetic hypersensitivity of unc-79 and unc-80 mutants. e5/Df similar, null phenotype.ES3 ME0. OA>20: e42, e65 (pka unc-12, weaker), bx5::Tc1, st197, mn384 (weaker allele), etc.; also revertants bx5mn369 etc. Cloned: main transcript 2.9 kb, encodes predicted 522 aa membrane protein related to EAT-5, Drosophila passover (26%identity), etc; possible gap junction component. [Starich et al. 1993; Morgan and Sedensky 1994; EH; SP] | |||||||||
| [Hecht RM ] cold sensitive, uncoordinated kinker at 11C, WT at 23C, phenotype reversible within hours of temperature shift, throughout development. Dominant interaction with some unc-7 alleles. NA1. | |||||||||
| [C.elegansII] hs10cs : uncoordinated at 11C, kinker;WT 23C; phenotype reversible within hoursof temp shift, throughout development. Dominant interaction with some unc-7vt-4alleles. NA1,[HH] | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (33) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | unc-7 encodes an innexin required for gap junction formation in invertebrates; UNC-7 is also required for normal locomotion, egg-laying, inhibition of feeding by tapping, avermectin sensitivity, and ivermectin sensitivity, as well as for the antagonism of UNC-79 and UNC-80 activity by volatile anesthetics; unc-7 is genetically required, and transcribed in, neurons rather than muscle cells, from larval stages L1 through L4; homologs of UNC-7 include Drosophila OGRE and SHAKING-B, as well as 24 C. elegans paralogs (including EAT-5, UNC-9, and INX-1 through INX-20); UNC-7 genetically interacts with UNC-124, and unc-7 mutants are phenotypically similar to unc-9 and unc-124 mutants; UNC-7 genetically interacts with AVR-14 and GLC-1 in the response to ivermectin. | Paper_evidence (11) | ||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables gap junction channel activity. Involved in several processes, including regulation of multicellular organismal process; reproductive behavior; and response to anesthetic. Located in gap junction and neuron projection membrane. Expressed in several structures, including OL socket cell; intestine; muscle cell; neurons; and pharyngeal gland cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R07D5.1a | |||||||
| R07D5.1b | |||||||||
| R07D5.1c | |||||||||
| R07D5.1d | |||||||||
| R07D5.1e | |||||||||
| R07D5.1f | |||||||||
| R07D5.1g | |||||||||
| R07D5.1h | |||||||||
| R07D5.1i | |||||||||
| R07D5.1j | |||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence (45) | |||||||||
| Associated_feature (33) | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern (20) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00013477 | ||||||||
| WBCnstr00014601 | |||||||||
| WBCnstr00020987 | |||||||||
| WBCnstr00020988 | |||||||||
| WBCnstr00021037 | |||||||||
| WBCnstr00022281 | |||||||||
| WBCnstr00022773 | |||||||||
| WBCnstr00033676 | |||||||||
| WBCnstr00034176 | |||||||||
| WBCnstr00042489 | |||||||||
| Antibody | WBAntibody00000520 | ||||||||
| WBAntibody00001906 | |||||||||
| WBAntibody00001921 | |||||||||
| Microarray_results (40) | |||||||||
| Expression_cluster (145) | |||||||||
| Interaction (84) | |||||||||
| Map_info | Map | X | Position | 22.0336 | Error | 0.049576 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDf19 | |||||||
| mnDp26 | |||||||||
| Positive_clone | C26D6 | ||||||||
| R07D5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point (17) | ||||||||
| Multi_point (26) | |||||||||
| Pos_neg_data (23) | |||||||||
| Landmark_gene | |||||||||
| Reference (115) | |||||||||
| Remark | Cloned, positive rescue by ZK1098 [Byrd D, Jin Y]. krb 14/11/01 | ||||||||
| Method | Gene |
