WormBase Tree Display for Gene: WBGene00006565
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| WBGene00006565 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y63D3A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | tfg-1 | |||||||
| Sequence_name | Y63D3A.5 | ||||||||
| Molecular_name | Y63D3A.5 | ||||||||
| Y63D3A.5.1 | |||||||||
| CE20336 | |||||||||
| Y63D3A.5.2 | |||||||||
| Other_name | CELE_Y63D3A.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | tfg-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tfg | ||||||||
| Allele (65) | |||||||||
| Strain | WBStrain00037094 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (21) | |||||||||
| Paralog | WBGene00013507 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | tfg-1 encodes a tumor suppressor gene homologous to human TRK-fused gene (TFG)(OMIM: 602498); TFG-1 is sufficient and necessary to inhibit the normal apoptotic pathway; TFG-1 influences body size and responsible for determining the size of adults; TFG-1 functions in a novel pathway independent of TGF-beta; and insulin signaling to control cell growth and size; TFG-1 directly interacts with SEC-16 and controls COPII subunit accumulation at the endoplasmic reticulum exit sites; TFG-1 requires SEC-16 for its localization and SEC-16 requires TFG-1 to accumulate normally on endoplasmic reticulum exit sites; TFG-1 hexamers facilitates normal assembly of large complexes containing SEC-16 and COPII subunits; TFG-1 depletion leads to a defect in normal Golgi assembly; analogously to C. elegans TFG-1, human TFG functions at endoplasmic reticulum exit sites; TFG-1 is detectable as early as the two cell stage of embryogenesis and expression continues throughout embryogenesis, punctated pattern in cytoplasm colocalizing with mitochondrial COX1. | Paper_evidence | WBPaper00032029 | |||||
| WBPaper00038310 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 20 Jul 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable identical protein binding activity. Involved in several processes, including cellular localization; regulation of cell growth; and regulation of cell size. Located in endoplasmic reticulum exit site and mitochondrion. Expressed in germ line; hypodermis; intestine; and muscle cell. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Is an ortholog of human TFG (trafficking from ER to golgi regulator). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110809 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11758) | ||||
| Molecular_info | Corresponding_CDS | Y63D3A.5 | |||||||
| Corresponding_transcript | Y63D3A.5.1 | ||||||||
| Y63D3A.5.2 | |||||||||
| Other_sequence (37) | |||||||||
| Associated_feature | WBsf643832 | ||||||||
| WBsf657064 | |||||||||
| WBsf981137 | |||||||||
| WBsf986048 | |||||||||
| WBsf986049 | |||||||||
| WBsf986050 | |||||||||
| WBsf1011187 | |||||||||
| WBsf218772 | |||||||||
| Experimental_info | RNAi_result (41) | ||||||||
| Expr_pattern | Expr8207 | ||||||||
| Expr9302 | |||||||||
| Expr1010574 | |||||||||
| Expr1032703 | |||||||||
| Expr1161314 | |||||||||
| Expr2017377 | |||||||||
| Expr2035514 | |||||||||
| Antibody | WBAntibody00001440 | ||||||||
| WBAntibody00002222 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (128) | |||||||||
| Interaction (306) | |||||||||
| Map_info | Map | I | Position | 23.1465 | Error | 0.009709 | |||
| Positive | Positive_clone | Y63D3A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00024063 | ||||||||
| WBPaper00031805 | |||||||||
| WBPaper00032029 | |||||||||
| WBPaper00038310 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062388 | |||||||||
| Remark | Sequence connection from [Mencinger M, Aman P] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
