WormBase Tree Display for Gene: WBGene00005157
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| WBGene00005157 | Identity | Version | 1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | CGC_name | srf-8 | Person_evidence | WBPerson494 | |||||
| Public_name | srf-8 | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Gene_class | srf | |||||||
| Allele | WBVar00142871 | Inferred_automatically | From strain object: CL264 | ||||||
| Legacy_information | [C.elegansII] dv38 : altered cuticle labelling, ectopic WGA lectin binding, pleiotropic defects: Unc, Egl, Mab, Mig(DTC), variable neuronal abnormalities,SDS-sensitive dauers; enhance lin-12(gf),[Link et al. 1992; CL] | ||||||||
| Strain | WBStrain00005059 | ||||||||
| Structured_description | Concise_description | srf-8 was identified as a mutation that alters the surface antigenicity of the cuticle in C. elegans; srf-8 mutations show altered binding to antibodies raised against the cuticles of wild-type worms, and lectins like wheat germ agglutinin; srf-8 mutants also show uncoordinated movement, abnormal gonadal and male tail morphologies, and male infertility. | Paper_evidence | WBPaper00001576 | |||||
| WBPaper00001706 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 10 Oct 2011 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00031925 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Nov 2023 00:00:00 | ||||||||
| Disease_relevance | C. elegans is used as a model system to study bacterial adherence via biofilm formation and to identify genes in the infectious agent as well as the host that are required for infection; elegans srf genes are required for cuticle surface properties like binding to antigens, and for the adherence of bacterial pathogens like Yersinia pseduotuberculosis and Yersinia pestis via biofilms. | Homo sapiens | Paper_evidence | WBPaper00001706 | |||||
| WBPaper00026735 | |||||||||
| WBPaper00029153 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Mar 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000019 | ||||||||
| Experimental_info | Interaction | WBInteraction000052126 | |||||||
| Map_info | Map | V | Position | 3.15377 | Error | 0.146558 | |||
| Mapping_data | 2_point | 5510 | |||||||
| Multi_point | 1587 | ||||||||
| 1859 | |||||||||
| 1860 | |||||||||
| Pos_neg_data | 4515 | ||||||||
| 5508 | |||||||||
| 5509 | |||||||||
| Reference (12) | |||||||||
| Method | Gene |
