WormBase Tree Display for Gene: WBGene00005154
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| WBGene00005154 | Identity | Version | 1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | CGC_name | srf-4 | Person_evidence | WBPerson494 | |||||
| Public_name | srf-4 | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Gene_class | srf | |||||||
| Reference_allele | WBVar00054522 | ||||||||
| Allele | WBVar00054522 | Inferred_automatically | From strain object: CL183 | ||||||
| WBVar00054372 | |||||||||
| WBVar00142872 | |||||||||
| WBVar00142856 | |||||||||
| WBVar00142869 | |||||||||
| WBVar00142868 | |||||||||
| WBVar00142848 | |||||||||
| WBVar00054537 | |||||||||
| Legacy_information | [C.elegansII] ct109 : altered cuticle labelling, ectopic WGA lectin binding, pleiotropic defects: Unc, Egl, Mab, Mig (DTC), variable neuronal abnormalities, SDS-sensitive dauers; enhance lin-12(gf). OA7: ct113, dv11, dv39 etc. [Link et al. 1992; CL] | ||||||||
| Strain | WBStrain00005056 | ||||||||
| Structured_description | Concise_description | srf-4 was identified as a mutation that alters the surface antigenicity of the cuticle in C. elegans; srf-4 mutations show altered binding to antibodies raised against the cuticles of wild-type worms, and lectins like wheat germ agglutinin; the altered binding maybe the result of an expression of a new antigen that is likely hidden in wild type and thus cryptic to surface reactive reagents; in addition to change in cuticle reactivity, srf-4 mutants also show uncoordinated movement, abnormal gonadal and male tail morphologies, and male infertility. | Paper_evidence | WBPaper00001576 | |||||
| WBPaper00001002 | |||||||||
| WBPaper00001706 | |||||||||
| WBPaper00001280 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Oct 2011 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00006215 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Nov 2023 00:00:00 | ||||||||
| Disease_relevance | C. elegans is used as a model system to study bacterial adherence via biofilm formation and to identify genes in the infectious agent as well as the host that are required for infection; elegans srf genes are required for cuticle surface properties like binding to antigens, and for the adherence of bacterial pathogens like Yersinia pseduotuberculosis and Yersinia pestis via biofilms. | Homo sapiens | Paper_evidence | WBPaper00001706 | |||||
| WBPaper00026735 | |||||||||
| WBPaper00029153 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Mar 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000016 | ||||||||
| Experimental_info | Interaction | WBInteraction000052125 | |||||||
| WBInteraction000052128 | |||||||||
| WBInteraction000052129 | |||||||||
| Map_info | Map | V | Position | 24.1204 | Error | 0.145345 | |||
| Positive | Inside_rearr | ozDf1 | |||||||
| ozDf2 | |||||||||
| Mapping_data | Multi_point | 1598 | |||||||
| 1599 | |||||||||
| 1600 | |||||||||
| 1601 | |||||||||
| Pos_neg_data | 8971 | ||||||||
| 8978 | |||||||||
| Reference (13) | |||||||||
| Method | Gene |
