WormBase Tree Display for Gene: WBGene00004966
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| WBGene00004966 | SMap | S_parent | Sequence | T02E1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | spe-12 | Person_evidence | WBPerson252 | |||||
| Sequence_name | T02E1.1 | ||||||||
| Molecular_name | T02E1.1 | ||||||||
| T02E1.1.1 | |||||||||
| CE13046 | |||||||||
| Other_name | CELE_T02E1.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | spe-12 | ||||||||
| DB_info | Database | AceView | gene | 1I802 | |||||
| WormQTL | gene | WBGene00004966 | |||||||
| WormFlux | gene | WBGene00004966 | |||||||
| NDB | locus_tag | CELE_T02E1.1 | |||||||
| NCBI | gene | 172606 | |||||||
| RefSeq | protein | NM_059841.2 | |||||||
| TREEFAM | TREEFAM_ID | TF335861 | |||||||
| TrEMBL | UniProtAcc | G5EEF3 | |||||||
| UniProt_GCRP | UniProtAcc | G5EEF3 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spe | ||||||||
| Reference_allele | WBVar00087777 | ||||||||
| Allele (28) | |||||||||
| Legacy_information | hc76 : hermaphrodites produce nonfunctional sperm fertilization defective; males are fertile. Similar phenotype in hc76/Df. Self-fertility <1% (16x or 25x). ES2 (adult). NA1. | ||||||||
| Virgin hermaphrodites are self-sterile and lay many oocytes bu no eggs. | |||||||||
| [C.elegansII] hc76 : hermaphrodites produce nonfunctional sperm fertilization defective; males are fertile. Similar phenotype in hc76/Df. Spermatids activated by ionophores; arrest as spiky intermediates after protease activation. Self-fertility <1% (16C or 25C). ES2 (adult). NA1. Cloned: transcript only in spermatogenic germ line, predicted protein novel? [L'Hernault et al. 1988; Shakes and Ward 1989a; BA] | |||||||||
| Strain | WBStrain00000423 | ||||||||
| WBStrain00000387 | |||||||||
| WBStrain00000404 | |||||||||
| WBStrain00000418 | |||||||||
| WBStrain00004615 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00016057 | ||||||||
| 00016058 | |||||||||
| 00016059 | |||||||||
| Ortholog (17) | |||||||||
| Structured_description | Concise_description | spe-12 encodes a novel protein with a single transmembrane domain; spe-12 is required for hermaphrodite spermatogenesis or sperm activation but not for male-derived sperm activation (sperm activation is the morphogenesis of a round non-motile spermatid to an amoeboid crawling sperm); however, mutant hermaphrodite spe-12 spermatids can transactivate and form functional sperm during mating with males; however this transativation is not as efficient as wild-type indicating that spe-12 has a supplementary, non-essential role in mating-induced spermatid activation; spe-12 is expressed in the germline and is localized to the spermatid plasma membrane; genetic and phenotypic evidence suggests that spe-12 acts in a common pathway with spe-8, spe-19, spe-27 and spe-29. | Paper_evidence | WBPaper00001166 | |||||
| WBPaper00001174 | |||||||||
| WBPaper00003531 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 26 Jul 2010 00:00:00 | ||||||||
| Automated_description | Involved in spermatid development. Located in plasma membrane. Expressed in spermatid and in male. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T02E1.1 | |||||||
| Corresponding_transcript | T02E1.1.1 | ||||||||
| Associated_feature | WBsf981059 | ||||||||
| WBsf984373 | |||||||||
| WBsf1010201 | |||||||||
| WBsf219880 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027671 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00052208 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1322 | ||||||||
| Expr1017878 | |||||||||
| Expr1155840 | |||||||||
| Expr2016032 | |||||||||
| Expr2034267 | |||||||||
| Drives_construct | WBCnstr00035301 | ||||||||
| Construct_product | WBCnstr00035301 | ||||||||
| Antibody | WBAntibody00000224 | ||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction (40) | |||||||||
| WBProcess | WBbiopr:00000069 | ||||||||
| Map_info | Map | I | Position | 2.69907 | Error | 0.00454 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T02E1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZK260 | Person_evidence | WBPerson440 | |||||||
| Mapping_data | 2_point | 3199 | |||||||
| Multi_point | 1049 | ||||||||
| 3445 | |||||||||
| 4950 | |||||||||
| Pos_neg_data | 3187 | ||||||||
| 3188 | |||||||||
| 3189 | |||||||||
| Reference (40) | |||||||||
| Method | Gene |
