WormBase Tree Display for Gene: WBGene00004910
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| WBGene00004910 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T03F7 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | snf-11 | Person_evidence | WBPerson508 | |||||
| Sequence_name | T03F7.1 | ||||||||
| Molecular_name | T03F7.1 | ||||||||
| T03F7.1.1 | |||||||||
| CE40659 | |||||||||
| Other_name | gat-1 | Paper_evidence | WBPaper00024600 | ||||||
| CELE_T03F7.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | snf-11 | ||||||||
| DB_info | Database | AceView | gene | 5L784 | |||||
| WormQTL | gene | WBGene00004910 | |||||||
| WormFlux | gene | WBGene00004910 | |||||||
| NDB | locus_tag | CELE_T03F7.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004910|UniProtKB=G5EF43 | |||||||
| family | PTHR11616 | ||||||||
| NCBI | gene | 191770 | |||||||
| RefSeq | protein | NM_073472.8 | |||||||
| TrEMBL | UniProtAcc | G5EF43 | |||||||
| UniProt_GCRP | UniProtAcc | G5EF43 | |||||||
| OMIM | gene | 137165 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 28 Sep 2010 16:54:10 | WBPerson2970 | Name_change | Other_name | gat-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | snf | ||||||||
| Allele (59) | |||||||||
| Strain | WBStrain00033395 | ||||||||
| WBStrain00033396 | |||||||||
| WBStrain00033398 | |||||||||
| WBStrain00033399 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (40) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | snf-11 encodes an electrogenic, Na[+]/Cl[-]-coupled, high-affinity GABA transporter that is required in vivo for GABA uptake, and for normal aldicarb sensitivity; SNF-11 is orthologous to human SLC6A1 (OMIM:137165); SNF-11 is selective for GABA with a Kt of ~15 microM, has an EC50 value of 168 microM, is blocked by GAT1 inhibitor SKF89976A, and has a 2:1:1 stoichiometry of Na[+]:Cl[-]:GABA; SNF-11 is expressed in several GABAergic neurons, in some other non-GABAergic neurons of the head and retrovesicular ganglion (e.g., RID), and in muscle cells; snf-11(ok156) null mutants fail to show GABA uptake in at least some GABAergic cells, and in cell culture; snf-11(ok156) mutants exhibit GABA-dependent aldicarb resistance, and show abnormal head foraging and defecation in a genetically sensitized background (GABA-transport dependent, with an unc-25 null allele); while unsensitized snf-11(ok156) mutants have grossly normal phenotype, cell cultures from snf-11(ok156) embryos completely lack normal GABA uptake. | Paper_evidence | WBPaper00024600 | |||||
| WBPaper00027352 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 05 Jan 2008 00:00:00 | ||||||||
| Automated_description | Enables gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in gamma-aminobutyric acid transport. Located in neuron projection and neuronal cell body. Expressed in several structures, including GLR; enteric muscle; head mesodermal cell; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in myoclonic-atonic epilepsy and temporal lobe epilepsy. Is an ortholog of human SLC6A1 (solute carrier family 6 member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060475 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11042) | ||||
| DOID:0050741 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11042) | ||||||
| DOID:3328 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11042) | ||||||
| Molecular_info | Corresponding_CDS | T03F7.1 | |||||||
| Corresponding_CDS_history | T03F7.1:wp169 | ||||||||
| Corresponding_transcript | T03F7.1.1 | ||||||||
| Other_sequence (29) | |||||||||
| Associated_feature | WBsf668679 | ||||||||
| WBsf669372 | |||||||||
| WBsf716831 | |||||||||
| WBsf1001313 | |||||||||
| WBsf234522 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00052295 | Inferred_automatically | RNAi_primary | |||||
| Expr_pattern | Expr4376 | ||||||||
| Expr6581 | |||||||||
| Expr7836 | |||||||||
| Expr7837 | |||||||||
| Expr13160 | |||||||||
| Expr1018656 | |||||||||
| Expr1032440 | |||||||||
| Expr1155929 | |||||||||
| Expr2015944 | |||||||||
| Expr2034179 | |||||||||
| Drives_construct | WBCnstr00004041 | ||||||||
| WBCnstr00011950 | |||||||||
| WBCnstr00012949 | |||||||||
| WBCnstr00035328 | |||||||||
| Construct_product | WBCnstr00035328 | ||||||||
| Antibody | WBAntibody00001085 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (195) | |||||||||
| Interaction (11) | |||||||||
| Map_info | Map | V | Position | 3.07267 | Error | 0.000861 | |||
| Positive | Positive_clone | T03F7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4230 | |||||||
| 4365 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Sequence connection from [Rand JB] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
