WormBase Tree Display for Gene: WBGene00004321
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| WBGene00004321 | SMap | S_parent | Sequence | F54E7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | rcan-1 | Paper_evidence | WBPaper00048397 | |||||
| Person_evidence | WBPerson746 | ||||||||
| Sequence_name | F54E7.7 | ||||||||
| Molecular_name | F54E7.7 | ||||||||
| F54E7.7.1 | |||||||||
| CE31002 | |||||||||
| Other_name | DSCR1L | Accession_evidence | EMBL | AF176115 | |||||
| SC | Accession_evidence | EMBL | AF176115 | ||||||
| rcn-1 | Paper_evidence | WBPaper00005829 | |||||||
| Person_evidence | WBPerson746 | ||||||||
| CELE_F54E7.7 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | rcan-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 03 Sep 2015 10:04:07 | WBPerson2970 | Name_change | CGC_name | rcan-1 | ||||
| Other_name | rcn-1 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rcan | ||||||||
| Allele (25) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (43) | |||||||||
| Structured_description | Automated_description | Enables protein phosphatase 2B binding activity and protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including male mating behavior; positive regulation of nematode male tail tip morphogenesis; and thermosensory behavior. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including non-striated muscle; pharyngeal cell; somatic nervous system; tail; and vulva. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human RCAN1 (regulator of calcineurin 1); RCAN2 (regulator of calcineurin 2); and RCAN3 (RCAN family member 3). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14250 | Homo sapiens | Paper_evidence | WBPaper00005829 | ||||
| Accession_evidence | OMIM | 190685 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2017 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3040) | |||||
| Disease_relevance | DSCR1) gene is located in the Down Syndrome critical region (DSCR) of chromosome 21, and encodes an inhibitor of calcineurin-signalling pathways; in elegans, overexpression of rcan-1 could reproduce calcineurin loss-of-function phenotypes, providing in vivo proof of rcan-1 regulation of calcineurin; also, as with mbk-1, another DSCR gene ortholog in elegans, adjusting rcan-1 dosage could reverse the effects of its overexpression. | Homo sapiens | Paper_evidence | WBPaper00005829 | |||||
| Accession_evidence | OMIM | 190685 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2017 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000131 | ||||||||
| Molecular_info | Corresponding_CDS | F54E7.7 | |||||||
| Corresponding_transcript | F54E7.7.1 | ||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf666918 | ||||||||
| WBsf992489 | |||||||||
| WBsf992490 | |||||||||
| WBsf992491 | |||||||||
| WBsf226716 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00048353 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00015642 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005533 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027915 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2548 | ||||||||
| Expr11062 | |||||||||
| Expr13659 | |||||||||
| Expr1011498 | |||||||||
| Expr1032146 | |||||||||
| Expr1152149 | |||||||||
| Expr2015278 | |||||||||
| Expr2033512 | |||||||||
| Drives_construct | WBCnstr00008158 | ||||||||
| WBCnstr00010850 | |||||||||
| WBCnstr00037927 | |||||||||
| WBCnstr00039931 | |||||||||
| Construct_product | WBCnstr00008158 | ||||||||
| WBCnstr00037927 | |||||||||
| WBCnstr00039931 | |||||||||
| Antibody | WBAntibody00002649 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (198) | |||||||||
| Interaction (169) | |||||||||
| Map_info | Map | III | Position | -1.45588 | Error | 0.000648 | |||
| Positive | Positive_clone | F54E7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5250 | |||||||
| 5049 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (25) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
