WormBase Tree Display for Gene: WBGene00004231

WBGene00004231 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y18D10A
  Identity: Version: 1
    Name: CGC_name: ptr-17 Person_evidence: WBPerson349
      Sequence_name: Y18D10A.7
      Molecular_name: Y18D10A.7
        Y18D10A.7.1
        CE53875
      Other_name: CELE_Y18D10A.7 Accession_evidence: NDB BX284601
      Public_name: ptr-17
    DB_info: Database: AceView gene 1N433
        WormQTL gene WBGene00004231
        WormFlux gene WBGene00004231
        NDB locus_tag CELE_Y18D10A.7
        Panther gene CAEEL|WormBase=WBGene00004231|UniProtKB=Q5DTE5
          family PTHR10796
        NCBI gene 173150
        RefSeq protein NM_001377664.2
        TrEMBL UniProtAcc A0A5S9MNL4
        UniProt_GCRP UniProtAcc A0A5S9MNL4
        OMIM gene 300828
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ptr
    Allele (156)
    RNASeq_FPKM (74)
    GO_annotation: 00004192
      00004193
      00004194
      00004195
      00004196
      00112523
    Ortholog (51)
    Paralog (30)
    Structured_description: Concise_description: ptr-17 encodes a divergent ortholog of Drosophila and human PTCHD3,which defines one of seven paralogous families of sterol sensing domain(SSD) proteins; PTR-17 is required for normal adult alae formation. Paper_evidence: WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson567
          Date_last_updated: 08 Nov 2006 00:00:00
      Automated_description: Predicted to be involved in endocytosis and molting cycle. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder. Is an ortholog of human PTCHD1 (patched domain containing 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:12849 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:26392)
  Molecular_info: Corresponding_CDS: Y18D10A.7
    Corresponding_CDS_history: Y18D10A.7:wp104
      Y18D10A.7:wp139
      Y18D10A.7a:wp274
      Y18D10A.7b:wp274
      Y18D10A.7c:wp274
    Corresponding_transcript: Y18D10A.7.1
    Other_sequence: AS15382
      ASC17683_1
      JI168139.1
      Dviv_isotig30522
      JI219817.1
      ACC08186_1
      FE909914.1
      BMC06021_1
      EX548935.1
    Associated_feature: WBsf985698
      WBsf985699
      WBsf985700
      WBsf985701
      WBsf985702
      WBsf985703
      WBsf1010972
      WBsf1010973
      WBsf1010974
      WBsf1010975
  Experimental_info: RNAi_result: WBRNAi00076925 Inferred_automatically: RNAi_primary
      WBRNAi00076957 Inferred_automatically: RNAi_primary
      WBRNAi00076968 Inferred_automatically: RNAi_primary
      WBRNAi00055621 Inferred_automatically: RNAi_primary
      WBRNAi00036699 Inferred_automatically: RNAi_primary
      WBRNAi00004547 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1017885
      Expr1159131
      Expr2015160
      Expr2033398
    Microarray_results (32)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
      WBPaper00044037:eat-2_regulated_nhr-62_dependent
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045017:blmp-1(tm548)_downregulated
      WBPaper00045401:N.parisii_64h_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00048923:Aging_regulated
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049635:dop-1(vs100)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050193:cec-4(ok3124)_upregulated_L1
      WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-5(ram2)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053402:cco-1(RNAi)_downregulated
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055013:hmg-4(RNAi)_downregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055354:Metformin_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Psora_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_L2
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059231:alh-6(lax105)_L4_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061340:ADEsh
      WBPaper00061340:AMso
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:C54G4.4-Y45F3A.8
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061952:daf-18(nr2037)_upregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:151
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065841:34_0
      WBPaper00065841:34_1
      WBPaper00065841:64_0
      WBPaper00065841:82_1
      WBPaper00065841:86_0
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_G
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00045673:colistin_upregulated
      WBPaper00046083:oga-1(ok1207)_OP50_downregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction (23)
  Map_info: Map: I Position: 14.1442 Error: 0.002279
    Positive: Positive_clone: Y18D10A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00004265
    WBPaper00026841
    WBPaper00038491
    WBPaper00055090
    WBPaper00064105
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene