WormBase Tree Display for Gene: WBGene00004210

WBGene00004210 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y110A2AL
  Identity: Version: 1
    Name: CGC_name: ptc-3 Person_evidence: WBPerson349
      Sequence_name: Y110A2AL.8
      Molecular_name: Y110A2AL.8a
        Y110A2AL.8a.1
        CE37163
        Y110A2AL.8b
        CE37164
        Y110A2AL.8c
        CE42182
        Y110A2AL.8b.1
        Y110A2AL.8c.1
      Other_name: Y110A2AL.j Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y110A2AL.8 Accession_evidence: NDB BX284602
      Public_name: ptc-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ptc
    Allele (195)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (41)
    Paralog (31)
    Structured_description: Concise_description: ptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-3 is strongly required for normal molting from L1 to L3 larvalstages; PTC-3 is also required for normal growth to full size and forviability. Paper_evidence (3)
          Curator_confirmed: WBPerson567
          Date_last_updated: 08 Nov 2006 00:00:00
      Automated_description: Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CEP; cloaca; egg-laying apparatus; excretory duct; and preanal ganglion. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (18)
  Molecular_info: Corresponding_CDS: Y110A2AL.8a
      Y110A2AL.8b
      Y110A2AL.8c
    Corresponding_CDS_history: Y110A2AL.8a:wp127
      Y110A2AL.8b:wp127
    Corresponding_transcript: Y110A2AL.8a.1
      Y110A2AL.8b.1
      Y110A2AL.8c.1
    Other_sequence (34)
    Associated_feature (13)
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr9231
      Expr9232
      Expr1017786
      Expr1032067
      Expr1158842
      Expr2015145
      Expr2033383
    Drives_construct: WBCnstr00008494
      WBCnstr00008496
      WBCnstr00035634
    Construct_product: WBCnstr00008494
      WBCnstr00008495
      WBCnstr00008496
      WBCnstr00008497
      WBCnstr00008498
      WBCnstr00008502
      WBCnstr00035634
    Antibody: WBAntibody00002998
    Microarray_results (31)
    Expression_cluster (200)
    Interaction: WBInteraction000009897
      WBInteraction000028310
      WBInteraction000028552
      WBInteraction000028554
      WBInteraction000028556
      WBInteraction000028680
      WBInteraction000028682
      WBInteraction000028740
      WBInteraction000028886
      WBInteraction000029173
      WBInteraction000032567
      WBInteraction000032777
      WBInteraction000032783
      WBInteraction000032785
      WBInteraction000032965
      WBInteraction000033294
      WBInteraction000033434
      WBInteraction000034524
      WBInteraction000034550
      WBInteraction000034633
      WBInteraction000035131
      WBInteraction000035271
      WBInteraction000036312
      WBInteraction000038139
      WBInteraction000038356
      WBInteraction000038527
      WBInteraction000038658
      WBInteraction000039008
      WBInteraction000039608
      WBInteraction000040024
      WBInteraction000040175
      WBInteraction000040610
      WBInteraction000040633
      WBInteraction000040736
      WBInteraction000040891
      WBInteraction000040939
      WBInteraction000041239
      WBInteraction000041340
      WBInteraction000041766
      WBInteraction000043132
      WBInteraction000043471
      WBInteraction000043539
      WBInteraction000043735
      WBInteraction000044290
      WBInteraction000044416
      WBInteraction000044434
      WBInteraction000044462
      WBInteraction000044817
      WBInteraction000044833
      WBInteraction000044838
      WBInteraction000046122
      WBInteraction000046515
      WBInteraction000047175
      WBInteraction000047352
      WBInteraction000047731
      WBInteraction000048522
      WBInteraction000049040
      WBInteraction000049126
      WBInteraction000049411
      WBInteraction000049849
      WBInteraction000114599
      WBInteraction000114601
      WBInteraction000114603
      WBInteraction000114605
      WBInteraction000114615
      WBInteraction000114616
      WBInteraction000114617
      WBInteraction000114618
      WBInteraction000114626
      WBInteraction000161029
      WBInteraction000161045
      WBInteraction000161046
      WBInteraction000162357
      WBInteraction000172934
      WBInteraction000502478
      WBInteraction000551578
      WBInteraction000554221
      WBInteraction000580274
    WBProcess: WBbiopr:00000123
  Map_info: Map: II Position: -9.82406 Error: 0.084736
    Positive: Positive_clone: Y110A2AL Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (21)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene