WormBase Tree Display for Gene: WBGene00004210
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WBGene00004210 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y110A2AL | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ptc | ||||||
Allele (195) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (41) | |||||||
Paralog (31) | |||||||
Structured_description | Concise_description | ptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-3 is strongly required for normal molting from L1 to L3 larvalstages; PTC-3 is also required for normal growth to full size and forviability. | Paper_evidence | WBPaper00004265 | |||
WBPaper00026841 | |||||||
WBPaper00027263 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 08 Nov 2006 00:00:00 | ||||||
Automated_description | Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CEP; cloaca; egg-laying apparatus; excretory duct; and preanal ganglion. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (18) | ||||||
Molecular_info | Corresponding_CDS | Y110A2AL.8a | |||||
Y110A2AL.8b | |||||||
Y110A2AL.8c | |||||||
Corresponding_CDS_history | Y110A2AL.8a:wp127 | ||||||
Y110A2AL.8b:wp127 | |||||||
Corresponding_transcript | Y110A2AL.8a.1 | ||||||
Y110A2AL.8b.1 | |||||||
Y110A2AL.8c.1 | |||||||
Other_sequence | CRC01499_1 | ||||||
JI466102.1 | |||||||
FC542662.1 | |||||||
RS10592 | |||||||
Oden_isotig18879 | |||||||
TSC10955_1 | |||||||
HBC18725_1 | |||||||
EX564995.1 | |||||||
BMC12862_1 | |||||||
Dviv_isotig06231 | |||||||
CBC13056_1 | |||||||
Dviv_isotig06232 | |||||||
CR01496 | |||||||
MAC02080_1 | |||||||
BM00762 | |||||||
MA01112 | |||||||
EX501518.1 | |||||||
Acan_isotig02692 | |||||||
JI479119.1 | |||||||
ES567197.1 | |||||||
CR02074 | |||||||
JI164462.1 | |||||||
DN153091.1 | |||||||
ACC30645_1 | |||||||
RS06795 | |||||||
RSC04460_1 | |||||||
FC548736.1 | |||||||
Dviv_contig12364 | |||||||
FC549925.1 | |||||||
MHC09340_1 | |||||||
TSC07345_1 | |||||||
ACC24546_1 | |||||||
Acan_isotig02691 | |||||||
CRC04917_1 | |||||||
Associated_feature (13) | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern | Expr9231 | ||||||
Expr9232 | |||||||
Expr1017786 | |||||||
Expr1032067 | |||||||
Expr1158842 | |||||||
Expr2015145 | |||||||
Expr2033383 | |||||||
Drives_construct | WBCnstr00008494 | ||||||
WBCnstr00008496 | |||||||
WBCnstr00035634 | |||||||
Construct_product | WBCnstr00008494 | ||||||
WBCnstr00008495 | |||||||
WBCnstr00008496 | |||||||
WBCnstr00008497 | |||||||
WBCnstr00008498 | |||||||
WBCnstr00008502 | |||||||
WBCnstr00035634 | |||||||
Antibody | WBAntibody00002998 | ||||||
Microarray_results (31) | |||||||
Expression_cluster (200) | |||||||
Interaction (78) | |||||||
WBProcess | WBbiopr:00000123 | ||||||
Map_info | Map | II | Position | -9.82406 | Error | 0.084736 | |
Positive | Positive_clone | Y110A2AL | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (21) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |