WormBase Tree Display for Gene: WBGene00004194
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| WBGene00004194 | SMap | S_parent | Sequence | C34C6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | prx-5 | |||||||
| Sequence_name | C34C6.6 | ||||||||
| Molecular_name | C34C6.6a | ||||||||
| C34C6.6a.1 | |||||||||
| CE03054 | |||||||||
| C34C6.6b | |||||||||
| CE36377 | |||||||||
| C34C6.6b.1 | |||||||||
| Other_name | CELE_C34C6.6 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | prx-5 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | prx | ||||||||
| Allele (30) | |||||||||
| Strain | WBStrain00026539 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals. | Paper_evidence | WBPaper00004395 | |||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables peroxisome targeting sequence binding activity. Involved in nematode larval development and protein import into peroxisome matrix. Predicted to be located in cytosol and peroxisomal membrane. Expressed in neurons. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Is an ortholog of human PEX5 (peroxisomal biogenesis factor 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110854 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9719) | ||||
| DOID:0080622 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9719) | ||||||
| DOID:0080477 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9719) | ||||||
| Molecular_info | Corresponding_CDS | C34C6.6a | |||||||
| C34C6.6b | |||||||||
| Corresponding_transcript | C34C6.6a.1 | ||||||||
| C34C6.6b.1 | |||||||||
| Other_sequence (27) | |||||||||
| Associated_feature | WBsf644497 | ||||||||
| WBsf221804 | |||||||||
| Experimental_info | RNAi_result (33) | ||||||||
| Expr_pattern | Expr11271 | ||||||||
| Expr1023878 | |||||||||
| Expr1032054 | |||||||||
| Expr1145873 | |||||||||
| Expr2015127 | |||||||||
| Expr2033365 | |||||||||
| Drives_construct | WBCnstr00018529 | ||||||||
| WBCnstr00035645 | |||||||||
| WBCnstr00038169 | |||||||||
| Construct_product | WBCnstr00035645 | ||||||||
| WBCnstr00038169 | |||||||||
| Regulate_expr_cluster | WBPaper00060911:prx-5(RNAi)_downregulated_mRNA | ||||||||
| WBPaper00060911:prx-5(RNAi)_downregulated_protein | |||||||||
| WBPaper00060911:prx-5(RNAi)_upregulated_mRNA | |||||||||
| WBPaper00060911:prx-5(RNAi)_upregulated_protein | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (165) | |||||||||
| Map_info | Map | II | Position | 0.849291 | Error | 0.001325 | |||
| Positive | Positive_clone | C34C6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | Sequence connection from [Motley AM, Plasterk RHA], 02/06/13 krb. | ||||||||
| Note that some Authors have incorrectly published prx genes as pex genes. pex genes are a separate class of gene not related to prx genes[JAH][030108 ck1] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
