WormBase Tree Display for Gene: WBGene00003964
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| WBGene00003964 | SMap | S_parent | Sequence | H06O01 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pdi-3 | Person_evidence | WBPerson466 | |||||
| Sequence_name | H06O01.1 | ||||||||
| Molecular_name | H06O01.1 | ||||||||
| H06O01.1.1 | |||||||||
| CE11570 | |||||||||
| H06O01.1.2 | |||||||||
| Other_name | CELE_H06O01.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | pdi-3 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pdi | ||||||||
| Allele (54) | |||||||||
| Strain | WBStrain00047528 | ||||||||
| WBStrain00055430 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | pdi-3 encodes a protein disulfide isomerase (PDI) required for normal cuticle collagen deposition and, subliminally, for maintenance of normal body shape; PDI-3 has both PDI and calcium-dependent transglutaminase activity in vitro, crosslinking proteins through a gamma-glutamyl epsilon-lysine dual residue; PDI-3 is homologous to the human PDI ERp60, as well as a homolog in the dog heartworm Dirofilaria immitis that is required for larval molting; the joint PDI/transglutaminase activity of PDI-3 is biochemically conserved in nematodes and mammals; pdi-3 is constitutively and broadly expressed, particularly in gut and hypodermis. | Paper_evidence | WBPaper00004402 | |||||
| WBPaper00004424 | |||||||||
| WBPaper00005011 | |||||||||
| WBPaper00005704 | |||||||||
| WBPaper00005848 | |||||||||
| WBPaper00012832 | |||||||||
| WBPaper00013043 | |||||||||
| WBPaper00013217 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables protein disulfide isomerase activity and protein-glutamine gamma-glutamyltransferase activity. Involved in several processes, including collagen and cuticulin-based cuticle development; egg-laying behavior; and male anatomical structure morphogenesis. Predicted to be located in endoplasmic reticulum. Expressed in hypodermis; intestine; and seam cell. Human ortholog(s) of this gene implicated in autoimmune hepatitis and liver cirrhosis. Is an ortholog of human PDIA3 (protein disulfide isomerase family A member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2048 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4606) | ||||
| DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4606) | ||||||
| Molecular_info | Corresponding_CDS | H06O01.1 | |||||||
| Corresponding_transcript | H06O01.1.1 | ||||||||
| H06O01.1.2 | |||||||||
| Other_sequence (166) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern | Expr2298 | ||||||||
| Expr2299 | |||||||||
| Expr2350 | |||||||||
| Expr2351 | |||||||||
| Expr2352 | |||||||||
| Expr1024250 | |||||||||
| Expr1031888 | |||||||||
| Expr1153069 | |||||||||
| Expr2014807 | |||||||||
| Expr2033041 | |||||||||
| Drives_construct | WBCnstr00010756 | ||||||||
| WBCnstr00010786 | |||||||||
| WBCnstr00035769 | |||||||||
| Construct_product | WBCnstr00010756 | ||||||||
| WBCnstr00010786 | |||||||||
| WBCnstr00035769 | |||||||||
| Antibody | WBAntibody00000601 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (165) | |||||||||
| Interaction (89) | |||||||||
| WBProcess | WBbiopr:00000124 | ||||||||
| Map_info | Map | I | Position | 1.65339 | Error | 0.000736 | |||
| Positive | Positive_clone | H06O01 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
