WormBase Tree Display for Gene: WBGene00003829
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| WBGene00003829 | SMap | S_parent | Sequence | F53A2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nud-1 | Person_evidence | WBPerson87 | |||||
| Sequence_name | F53A2.4 | ||||||||
| Molecular_name | F53A2.4 | ||||||||
| F53A2.4.1 | |||||||||
| CE16096 | |||||||||
| Other_name | CELE_F53A2.4 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | nud-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nud | ||||||||
| Allele (18) | |||||||||
| Strain | WBStrain00035169 | ||||||||
| WBStrain00031486 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Contained_in_operon | CEOP3784 | ||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | nud-1 encodes the C. elegans ortholog of the Aspergillus nidulans nudC, which mediates nuclear migration along Aspergillus hyphae. | Paper_evidence | WBPaper00004895 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables identical protein binding activity and unfolded protein binding activity. Involved in several processes, including GABAergic synaptic transmission; chaperone-mediated protein folding; and establishment of organelle localization. Predicted to be located in cytoplasm. Expressed in gonad; hypodermis; intestine; and neurons. Used to study epilepsy and lissencephaly. Is an ortholog of human NUDC (nuclear distribution C, dynein complex regulator). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Aug 2021 00:00:00 | ||||||||
| DOID:0050453 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||||||
| Accession_evidence | OMIM | 607432 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Apr 2013 00:00:00 | ||||||||
| Disease_relevance | In humans, mutations in the LIS1 gene (Platelet activating factor acetylhydrolase, isoform 1B, alpha subunit; PAFAH1B1) and the LIS1 pathway, are implicated in Lissencephaly, a developmental abnormality associated with a failure of neuronal migration in the cerebral cortex, leading to mental retardation and epilepsy; human NDE1 and NDEL1, are effectors of LIS1; the elegans genetic model for epileptic siezures consists of lis-1 mutants that are responsive to the common seizure inducer pentylenetetrazole (PTZ) and diplay a distinct convulsive phenotype; worms depleted for LIS1 pathway components via RNA interference (NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1) also exhibited significant convulsions following PTZ treatment; further nud-1 (orthologous to human NUDC), nud-2/NDE1 and cdk-5 show significant enhancement in convulsions in a lis-1 heterozygous background when compared with the wild-type background; these animals are also less likely to recover when PTZ treatment is removed, when compared to wild-type; these studies show that while knocking down target genes (lis-1, cdk-5, and cdka-1 that function in neuronal migration), and their interacting proteins like nud-1, nud-2 and dhc-1, does not yield spontaneous convulsions in C. elegans, further alterations in the neural environment through the application of PTZ serve to pass a critical threshold within these animals. | Homo sapiens | Paper_evidence | WBPaper00024523 | |||||
| WBPaper00028525 | |||||||||
| Accession_evidence | OMIM | 601545 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Models_disease_in_annotation | WBDOannot00000148 | ||||||||
| WBDOannot00001010 | |||||||||
| Molecular_info | Corresponding_CDS | F53A2.4 | |||||||
| Corresponding_transcript | F53A2.4.1 | ||||||||
| Other_sequence (82) | |||||||||
| Associated_feature | WBsf994858 | ||||||||
| WBsf994859 | |||||||||
| WBsf225989 | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern | Expr2419 | ||||||||
| Expr10134 | |||||||||
| Expr1011738 | |||||||||
| Expr1031804 | |||||||||
| Expr1151858 | |||||||||
| Expr2014524 | |||||||||
| Expr2032763 | |||||||||
| Drives_construct | WBCnstr00000117 | ||||||||
| Construct_product | WBCnstr00007338 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction (45) | |||||||||
| Map_info | Map | III | Position | 21.2108 | Error | 0.000119 | |||
| Positive | Positive_clone | F53A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4503 | |||||||
| 4549 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
