WormBase Tree Display for Gene: WBGene00003704

WBGene00003704 SMap: S_parent: Sequence: Y45G5AM
  Identity: Version: 1
    Name: CGC_name: nhr-114 Person_evidence: WBPerson600
      Sequence_name: Y45G5AM.1
      Molecular_name: Y45G5AM.1a
        Y45G5AM.1a.1
        CE33735
        Y45G5AM.1d
        CE51628
        Y45G5AM.1b
        Y45G5AM.1c
        Y45G5AM.1d.1
      Other_name: CELE_Y45G5AM.1 Accession_evidence: NDB BX284605
      Public_name: nhr-114
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nhr
    Allele (76)
    Strain: WBStrain00036852
      WBStrain00007427
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (27)
    Paralog (216)
    Structured_description: Concise_description: nhr-114 encodes, by alternative splicing, two isoforms of a nuclear hormone receptor that specifically binds GPA-13 in yeast two-hybrid assays; the interaction of NHR-114 with GPA-13 is independent of whether GPA-13 is constitutively activated or not; NHR-114 is expressed in intestine (and weakly in hypodermal cells), with mainly nuclear localization. Paper_evidence: WBPaper00006194
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in regulation of gene expression. Acts upstream of with a positive effect on S-adenosylmethionine cycle. Located in nucleus. Expressed in germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human NR1H3 (nuclear receptor subfamily 1 group H member 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:13001 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:7693 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:5844 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:3526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:6713 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:1936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
  Molecular_info: Corresponding_CDS: Y45G5AM.1a
      Y45G5AM.1d
    Corresponding_CDS_history: Y45G5AM.1:wp97
      Y45G5AM.1b:wp253
    Corresponding_transcript: Y45G5AM.1b
      Y45G5AM.1c
      Y45G5AM.1a.1
      Y45G5AM.1d.1
    Other_sequence: CSC00551_1
      CBC02885_1
      CRC06189_1
      CBC03000_1
      HC07024
      CBC06116_1
      FD514251.1
      CR10753
      CGC01249_1
    Associated_feature: WBsf646747
      WBsf646748
      WBsf1019469
      WBsf231647
      WBsf231648
      WBsf231649
      WBsf231650
    Transcription_factor: WBTranscriptionFactor000567
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr2750
      Expr10759
      Expr1028755
      Expr1031725
      Expr1160103
      Expr2014012
      Expr2032252
    Drives_construct: WBCnstr00010930
    Construct_product: WBCnstr00010930
    Regulate_expr_cluster: WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
    Microarray_results (24)
    Expression_cluster (219)
    Interaction: WBInteraction000028643
      WBInteraction000029563
      WBInteraction000515250
      WBInteraction000523659
      WBInteraction000525457
      WBInteraction000525663
      WBInteraction000525700
      WBInteraction000525767
      WBInteraction000525882
      WBInteraction000525993
      WBInteraction000526096
      WBInteraction000526153
      WBInteraction000526258
      WBInteraction000526357
      WBInteraction000526421
      WBInteraction000526462
      WBInteraction000526509
      WBInteraction000526549
      WBInteraction000526615
      WBInteraction000526695
      WBInteraction000526705
      WBInteraction000526725
      WBInteraction000526755
      WBInteraction000526775
      WBInteraction000526776
      WBInteraction000526777
      WBInteraction000526778
      WBInteraction000526779
      WBInteraction000526780
      WBInteraction000526781
      WBInteraction000526782
      WBInteraction000526783
      WBInteraction000526784
      WBInteraction000526785
      WBInteraction000526786
      WBInteraction000526787
      WBInteraction000526788
      WBInteraction000526789
      WBInteraction000526790
      WBInteraction000526791
      WBInteraction000526792
      WBInteraction000526793
      WBInteraction000526794
      WBInteraction000526795
      WBInteraction000526796
      WBInteraction000526797
      WBInteraction000526798
      WBInteraction000526799
      WBInteraction000526800
      WBInteraction000526801
      WBInteraction000526802
      WBInteraction000526803
      WBInteraction000526804
      WBInteraction000526805
      WBInteraction000526806
      WBInteraction000526807
      WBInteraction000526808
      WBInteraction000526809
      WBInteraction000526810
      WBInteraction000526811
      WBInteraction000526812
      WBInteraction000526813
      WBInteraction000526814
      WBInteraction000526822
      WBInteraction000526833
      WBInteraction000526902
      WBInteraction000526928
      WBInteraction000526954
      WBInteraction000527069
      WBInteraction000527195
      WBInteraction000527289
      WBInteraction000527445
      WBInteraction000527564
      WBInteraction000527619
      WBInteraction000527722
      WBInteraction000527792
      WBInteraction000527833
      WBInteraction000527865
      WBInteraction000528002
      WBInteraction000528113
      WBInteraction000534948
      WBInteraction000534951
      WBInteraction000534975
      WBInteraction000535013
      WBInteraction000535085
      WBInteraction000542825
      WBInteraction000544342
      WBInteraction000546547
      WBInteraction000560750
    Anatomy_function: WBbtf0599
      WBbtf0600
  Map_info (3)
  Reference (15)
  Remark: yk709c2 - EST sequence gives exact hit to both this orf and C27C7.8 - which is actual source? tentatively assigned to ZK1025.9 since C27C7.8 appears to be partial gene (no obvious NR DNA binding domain sequences) - EST clone has DBD, so is ZK1025.9 [Sluder A][030102 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene