WormBase Tree Display for Gene: WBGene00003704
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WBGene00003704 | SMap | S_parent | Sequence | Y45G5AM | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | nhr | ||||||
Allele (76) | |||||||
Strain | WBStrain00036852 | ||||||
WBStrain00007427 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (19) | |||||||
Ortholog (27) | |||||||
Paralog (216) | |||||||
Structured_description | Concise_description | nhr-114 encodes, by alternative splicing, two isoforms of a nuclear hormone receptor that specifically binds GPA-13 in yeast two-hybrid assays; the interaction of NHR-114 with GPA-13 is independent of whether GPA-13 is constitutively activated or not; NHR-114 is expressed in intestine (and weakly in hypodermal cells), with mainly nuclear localization. | Paper_evidence | WBPaper00006194 | |||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in regulation of gene expression. Acts upstream of with a positive effect on S-adenosylmethionine cycle. Located in nucleus. Expressed in germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human NR1H3 (nuclear receptor subfamily 1 group H member 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:13001 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||
DOID:7693 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
DOID:6713 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
DOID:1936 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7966) | ||||
Molecular_info | Corresponding_CDS | Y45G5AM.1a | |||||
Y45G5AM.1d | |||||||
Corresponding_CDS_history | Y45G5AM.1:wp97 | ||||||
Y45G5AM.1b:wp253 | |||||||
Corresponding_transcript | Y45G5AM.1b | ||||||
Y45G5AM.1c | |||||||
Y45G5AM.1a.1 | |||||||
Y45G5AM.1d.1 | |||||||
Other_sequence | CSC00551_1 | ||||||
CBC02885_1 | |||||||
CRC06189_1 | |||||||
CBC03000_1 | |||||||
HC07024 | |||||||
CBC06116_1 | |||||||
FD514251.1 | |||||||
CR10753 | |||||||
CGC01249_1 | |||||||
Associated_feature | WBsf646747 | ||||||
WBsf646748 | |||||||
WBsf1019469 | |||||||
WBsf231647 | |||||||
WBsf231648 | |||||||
WBsf231649 | |||||||
WBsf231650 | |||||||
Transcription_factor | WBTranscriptionFactor000567 | ||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern | Expr2750 | ||||||
Expr10759 | |||||||
Expr1028755 | |||||||
Expr1031725 | |||||||
Expr1160103 | |||||||
Expr2014012 | |||||||
Expr2032252 | |||||||
Drives_construct | WBCnstr00010930 | ||||||
Construct_product | WBCnstr00010930 | ||||||
Regulate_expr_cluster | WBPaper00042194:nhr-114(RNAi)_downregulated | ||||||
WBPaper00042194:nhr-114(RNAi)_upregulated | |||||||
WBPaper00064539:nhr-114(gk849)_downregulated | |||||||
WBPaper00064539:nhr-114(gk849)_upregulated | |||||||
Microarray_results (24) | |||||||
Expression_cluster (219) | |||||||
Interaction (89) | |||||||
Anatomy_function | WBbtf0599 | ||||||
WBbtf0600 | |||||||
Map_info | Map | V | Position | -6.3139 | Error | 0.012518 | |
Positive | Positive_clone | Y45G5AM | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (15) | |||||||
Remark | yk709c2 - EST sequence gives exact hit to both this orf and C27C7.8 - which is actual source? tentatively assigned to ZK1025.9 since C27C7.8 appears to be partial gene (no obvious NR DNA binding domain sequences) - EST clone has DBD, so is ZK1025.9 [Sluder A][030102 ck1] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |