WormBase Tree Display for Gene: WBGene00003704

WBGene00003704 SMap: S_parent: Sequence: Y45G5AM
  Identity: Version: 1
    Name: CGC_name: nhr-114 Person_evidence: WBPerson600
      Sequence_name: Y45G5AM.1
      Molecular_name: Y45G5AM.1a
        Y45G5AM.1a.1
        CE33735
        Y45G5AM.1d
        CE51628
        Y45G5AM.1b
        Y45G5AM.1c
        Y45G5AM.1d.1
      Other_name: CELE_Y45G5AM.1 Accession_evidence: NDB BX284605
      Public_name: nhr-114
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nhr
    Allele (76)
    Strain: WBStrain00036852
      WBStrain00007427
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (27)
    Paralog (216)
    Structured_description: Concise_description: nhr-114 encodes, by alternative splicing, two isoforms of a nuclear hormone receptor that specifically binds GPA-13 in yeast two-hybrid assays; the interaction of NHR-114 with GPA-13 is independent of whether GPA-13 is constitutively activated or not; NHR-114 is expressed in intestine (and weakly in hypodermal cells), with mainly nuclear localization. Paper_evidence: WBPaper00006194
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in regulation of gene expression. Acts upstream of with a positive effect on S-adenosylmethionine cycle. Located in nucleus. Expressed in germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human NR1H3 (nuclear receptor subfamily 1 group H member 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:13001 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:7693 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:5844 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:3526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:6713 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
      DOID:1936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7966)
  Molecular_info: Corresponding_CDS: Y45G5AM.1a
      Y45G5AM.1d
    Corresponding_CDS_history: Y45G5AM.1:wp97
      Y45G5AM.1b:wp253
    Corresponding_transcript: Y45G5AM.1b
      Y45G5AM.1c
      Y45G5AM.1a.1
      Y45G5AM.1d.1
    Other_sequence: CSC00551_1
      CBC02885_1
      CRC06189_1
      CBC03000_1
      HC07024
      CBC06116_1
      FD514251.1
      CR10753
      CGC01249_1
    Associated_feature: WBsf646747
      WBsf646748
      WBsf1019469
      WBsf231647
      WBsf231648
      WBsf231649
      WBsf231650
    Transcription_factor: WBTranscriptionFactor000567
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr2750
      Expr10759
      Expr1028755
      Expr1031725
      Expr1160103
      Expr2014012
      Expr2032252
    Drives_construct: WBCnstr00010930
    Construct_product: WBCnstr00010930
    Regulate_expr_cluster: WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
    Microarray_results (24)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00035269:cde-1_regulated
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Spermatogenic
      WBPaper00045774:clk-1_downregulated
      WBPaper00046338:intestine_unique
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046499:AMPK_regulated
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046691:P1_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049736:15deg-then-25deg(12hr)_downregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050096:P.aeruginosa_downregulated
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050743:elli-1(sam-3)_upregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051039:intestine_enriched
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(ot267)_upregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:OP50_vs_PY79_upregulated_PY79
      WBPaper00054192:cold-shock_downregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_downregulated
      WBPaper00055941:nuo-6(qm200)_downregulated
      WBPaper00055944:C.butyricum_vs_OP50_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:gut-microbiota_downregulated
      WBPaper00056167:ifo-1(kc2)_upregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056586:kri-1(ok1251)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_downregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_downregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059763:neuron_acr-2(n2420gf)_regulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060703:nas-38(ok3407)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:HB115_downregulated
      WBPaper00061007:M.braciatum_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061007:X.citri_downregulated
      WBPaper00061040:FW1256_upregulated
      WBPaper00061081:E.faecalis_downregulated_N2
      WBPaper00061081:E.faecalis_downregulated_skpo-1(ok1640)
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061285:wounding_24h_downregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061527:T05E12.6_12439-T05E12.6_12396
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062305:P.brevicompactum_downregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062606:rotenone_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064632:daf-2(e1370)_downregulated_intestine
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064871:PA14-gacA()_downregulated_AWA
      WBPaper00064871:PA14_downregulated_AWA
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_downregulated
      WBPaper00065749:Heat-Shock-With-Recovery_downregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:0_0
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065995:M.humicola-extract_upregulated_N2
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      WBPaper00028789:PA14_vs_OP50_downregulated_4hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00035227:heat_shock_regulated
      WBPaper00035892:KIM5_vs_OP50_Down
      WBPaper00035892:Y.pestis_regulated
      WBPaper00036286:Pattern_C
      WBPaper00036464:S.aureus-RN6390_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00039851:Live_C_albicans_vs_HK_C_albicans
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_0.2mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00042204:Comamonas_DA1877_downregulated
      WBPaper00042258:DA1877_downregulated_GravidAdult
      WBPaper00042258:DA1877_downregulated_YoungAdult
      WBPaper00042258:HT115_downregulated_YoungAdult
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047021:MWCNT_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00050650:mBmkTX_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053688:E.faecalis_downregulated
      WBPaper00053688:E.faecium_downregulated
      WBPaper00055435:AuNPs_downregulated
      WBPaper00055435:MUA-AuNP-0.5_downregulated
      WBPaper00055435:MUA-AuNP-3_downregulated
    Interaction (89)
    Anatomy_function: WBbtf0599
      WBbtf0600
  Map_info: Map: V Position: -6.3139 Error: 0.012518
    Positive: Positive_clone: Y45G5AM Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: yk709c2 - EST sequence gives exact hit to both this orf and C27C7.8 - which is actual source? tentatively assigned to ZK1025.9 since C27C7.8 appears to be partial gene (no obvious NR DNA binding domain sequences) - EST clone has DBD, so is ZK1025.9 [Sluder A][030102 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene