WormBase Tree Display for Gene: WBGene00003555
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| WBGene00003555 | Evidence | Author_evidence | Moehrlen F | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F38E9 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | nas-39 | Person_evidence | WBPerson1103 | |||||
| Sequence_name | F38E9.2 | ||||||||
| Molecular_name | F38E9.2 | ||||||||
| F38E9.2.1 | |||||||||
| CE53415 | |||||||||
| F38E9.2.2 | |||||||||
| Other_name | CELE_F38E9.2 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | nas-39 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nas | ||||||||
| Allele (226) | |||||||||
| Strain | WBStrain00002589 | ||||||||
| WBStrain00036058 | |||||||||
| WBStrain00054913 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (47) | |||||||||
| Paralog (48) | |||||||||
| Structured_description | Concise_description | nas-39 encodes an astacin family zinc metalloprotease and the only BMP-1/Tolloid homolog in C. elegans; in Drosophila and vertebrates nas-39 homologues activate TGF-beta signals by cleaving chordin/SOG, an inhibitor keeping the TGF-beta in inactive form; however developmental processes known to be affected by TGF-beta signaling are unaffected in nas-39 mutants, suggesting that nas-39 is not required for TGF-beta signaling; nas-39 is expressed in the pharynx, intestine, vulval and body wall muscles, and many neurons. | Paper_evidence | WBPaper00035910 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Nov 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable metalloendopeptidase activity. Predicted to be involved in dorsal/ventral pattern formation and protein processing. Predicted to be located in extracellular space. Expressed in neurons and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; coronary artery disease; and osteogenesis imperfecta type 13. Is an ortholog of human BMP1 (bone morphogenetic protein 1) and TLL2 (tolloid like 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110111 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11843) | ||||
| DOID:0110342 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1067) | ||||||
| DOID:1682 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11843) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11843) | ||||||
| Molecular_info | Corresponding_CDS | F38E9.2 | |||||||
| Corresponding_CDS_history | F38E9.2:wp271 | ||||||||
| Corresponding_transcript | F38E9.2.1 | ||||||||
| F38E9.2.2 | |||||||||
| Other_sequence (13) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00046725 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00014575 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089071 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061417 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram745 | ||||||||
| Expr5995 | |||||||||
| Expr8932 | |||||||||
| Expr1010654 | |||||||||
| Expr1031620 | |||||||||
| Expr1150605 | |||||||||
| Expr2013885 | |||||||||
| Expr2032125 | |||||||||
| Drives_construct | WBCnstr00003148 | ||||||||
| WBCnstr00013627 | |||||||||
| WBCnstr00036046 | |||||||||
| Construct_product | WBCnstr00013627 | ||||||||
| WBCnstr00036046 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (88) | |||||||||
| Interaction (33) | |||||||||
| Map_info | Map | X | Position | 23.9842 | Error | 0.013555 | |||
| Positive | Positive_clone | F38E9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4983 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00006254 | ||||||||
| WBPaper00024242 | |||||||||
| WBPaper00025850 | |||||||||
| WBPaper00035910 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064099 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
