WormBase Tree Display for Gene: WBGene00003312
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| WBGene00003312 | Evidence | Paper_evidence | WBPaper00004928 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | B0395 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mir-84 | Person_evidence | WBPerson18 | |||||
| Sequence_name | B0395.4 | ||||||||
| Molecular_name | B0395.4 | ||||||||
| B0395.4a | |||||||||
| B0395.4b | |||||||||
| Other_name | cel-mir-84 | Remark | miRBase V21 import | ||||||
| Cel-Let-7-P7 | Remark | MirGeneDB 2.1 import | |||||||
| CELE_B0395.4 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | mir-84 | ||||||||
| DB_info | Database | miRBase | acc | MI0000055 | |||||
| SignaLink | mirna | cel-mir-84 | |||||||
| MirGeneDB | cel | Cel-Let-7-P7 | |||||||
| NDB | locus_tag | CELE_B0395.4 | |||||||
| NCBI | gene | 259849 | |||||||
| RefSeq | protein | NR_001261.2 | |||||||
| RNAcentral | URSid | URS0000189267 | |||||||
| URS00003205C8 | |||||||||
| URS0000465454 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001265 | |||||||
| Gene_class | mir | ||||||||
| Allele (11) | |||||||||
| Strain (24) | |||||||||
| In_cluster | LET-7 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00106255 | ||||||||
| 00106256 | |||||||||
| 00106257 | |||||||||
| 00106258 | |||||||||
| 00106259 | |||||||||
| Structured_description | Concise_description | mir-84 encodes a microRNA, a small non-protein coding RNA that appears to be conserved in Drosophila and humans; mir-84 is similar in sequence to the let-7 stRNA suggesting they may have the same target sites; mir-84 seems to act redundantly with other members of the let-7 family, mir-48 and mir-241 to control the L2 larval to L3 larval stage transition and larval to adult transition; an overexpression of mir-84 results in abnormal vulval and uterine morphologies; a mir-84-gfp fusion construct is expressed temporally in cells that give rise to the vulva and uterus; mir-84 is expressed starting from the L2 larval stage; mir-84 expression is promoted by lin-4. | Paper_evidence | WBPaper00004927 | |||||
| WBPaper00004928 | |||||||||
| WBPaper00019533 | |||||||||
| WBPaper00019534 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Feb 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable translation repressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of Ras protein signal transduction; and positive regulation of development, heterochronic. Expressed in several structures, including P5.ppp; gonad; somatic gonad precursor; touch receptor neurons; and vulval precursor cell. Used to study Parkinson's disease. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035654 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Disease_relevance | mir-84 is a small non-protein coding RNA that belongs to the let-7 family; microRNA expression profiling studies in an elegans transgenic model of Parkinson''s disease, where A53T alpha-synuclein is overexpressed, indicate that elegans mir-84 and mir-48 are underexpressed. | Homo sapiens | Paper_evidence | WBPaper00035654 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000267 | ||||||||
| Molecular_info | Corresponding_transcript | B0395.4 | |||||||
| B0395.4a | |||||||||
| B0395.4b | |||||||||
| Other_sequence | AJ487607 | ||||||||
| Associated_feature | WBsf979138 | ||||||||
| WBsf1008407 | |||||||||
| WBsf1008408 | |||||||||
| WBsf1024700 | |||||||||
| WBsf1024701 | |||||||||
| Experimental_info | Expr_pattern (13) | ||||||||
| Drives_construct | WBCnstr00000959 | ||||||||
| WBCnstr00000974 | |||||||||
| WBCnstr00000975 | |||||||||
| WBCnstr00000976 | |||||||||
| WBCnstr00005521 | |||||||||
| WBCnstr00011409 | |||||||||
| WBCnstr00015768 | |||||||||
| WBCnstr00015775 | |||||||||
| WBCnstr00017832 | |||||||||
| WBCnstr00021002 | |||||||||
| Construct_product | WBCnstr00000974 | ||||||||
| WBCnstr00000975 | |||||||||
| WBCnstr00000976 | |||||||||
| WBCnstr00015775 | |||||||||
| WBCnstr00016929 | |||||||||
| Expression_cluster (20) | |||||||||
| Interaction (62) | |||||||||
| WBProcess | WBbiopr:00000083 | ||||||||
| Map_info | Map | X | Position | 23.6761 | Error | 0.082927 | |||
| Positive | Positive_clone | B0395 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4658 | |||||||
| Pseudo_map_position | |||||||||
| Reference (72) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
