WormBase Tree Display for Gene: WBGene00003185
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| WBGene00003185 | SMap | S_parent | Sequence | K08A8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mek-1 | Person_evidence | WBPerson237 | |||||
| Sequence_name | K08A8.1 | ||||||||
| Molecular_name | K08A8.1a | ||||||||
| K08A8.1a.1 | |||||||||
| CE30816 | |||||||||
| K08A8.1b | |||||||||
| Other_name | kin-17 | ||||||||
| CELE_K08A8.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | mek-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mek | ||||||||
| Allele (31) | |||||||||
| Legacy_information | deletion mutant ks54: hypersensitive to starvation | ||||||||
| [C.elegansII] NMK. Encodes predicted protein kinase. [FK] | |||||||||
| Strain | WBStrain00028929 | ||||||||
| WBStrain00007509 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (45) | |||||||||
| Paralog (25) | |||||||||
| Structured_description | Concise_description | mek-1 encodes a MAP kinase kinase (MAPKK) that is involved in the stress response to heavy metals and starvation, and that has the highest homology to mammalian MKK7. | Paper_evidence | WBPaper00004381 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables JUN kinase kinase activity and SH2 domain binding activity. Involved in several processes, including gamete generation; response to metal ion; and stress-activated MAPK cascade. Predicted to be located in cytoplasm. Expressed in several structures, including ganglia; hermaphrodite gonad; intestine; nerve ring; and pharynx. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K7 (mitogen-activated protein kinase kinase 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3905 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6847) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6847) | ||||||
| DOID:8634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6847) | ||||||
| DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6847) | ||||||
| DOID:234 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6847) | ||||||
| Molecular_info | Corresponding_CDS | K08A8.1a | |||||||
| Corresponding_CDS_history | K08A8.1b:wp248 | ||||||||
| Corresponding_transcript | K08A8.1b | ||||||||
| K08A8.1a.1 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf982197 | ||||||||
| WBsf1005853 | |||||||||
| WBsf1023258 | |||||||||
| WBsf235935 | |||||||||
| WBsf235936 | |||||||||
| WBsf235937 | |||||||||
| WBsf235938 | |||||||||
| WBsf235939 | |||||||||
| WBsf235940 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr1094 | ||||||||
| Expr8348 | |||||||||
| Expr13129 | |||||||||
| Expr1021554 | |||||||||
| Expr1031512 | |||||||||
| Expr1153913 | |||||||||
| Expr2013514 | |||||||||
| Expr2031748 | |||||||||
| Drives_construct | WBCnstr00010077 | ||||||||
| WBCnstr00013272 | |||||||||
| WBCnstr00020153 | |||||||||
| WBCnstr00020154 | |||||||||
| WBCnstr00036186 | |||||||||
| Construct_product | WBCnstr00010077 | ||||||||
| WBCnstr00017215 | |||||||||
| WBCnstr00018064 | |||||||||
| WBCnstr00020122 | |||||||||
| WBCnstr00020123 | |||||||||
| WBCnstr00036186 | |||||||||
| Antibody | WBAntibody00001470 | ||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (184) | |||||||||
| Interaction (174) | |||||||||
| WBProcess | WBbiopr:00000052 | ||||||||
| WBbiopr:00000096 | |||||||||
| Map_info | Map | X | Position | -1.67276 | Error | 0.002819 | |||
| Positive | Positive_clone | K08A8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| YO#L1-1 | |||||||||
| Mapping_data | Multi_point | 4360 | |||||||
| 4486 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (84) | |||||||||
| Picture | WBPicture0000013081 | ||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| K08A8.1 | Paper_evidence | WBPaper00004381 | |||||||
| Method | Gene |
