Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00002637

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00002637EvidenceCGC_data_submission
SMapS_parentSequenceF26F12
IdentityVersion1
NameCGC_namelet-418Person_evidenceWBPerson533
Sequence_nameF26F12.7
Molecular_nameF26F12.7
F26F12.7.1
CE17716
Other_nameevl-11
chd-4
CELE_F26F12.7Accession_evidenceNDBBX284605
Public_namelet-418
DB_infoDatabaseAceViewgene5G311
WormQTLgeneWBGene00002637
WormFluxgeneWBGene00002637
NDBlocus_tagCELE_F26F12.7
PanthergeneCAEEL|WormBase=WBGene00002637|UniProtKB=G5EBZ4
familyPTHR45623
NCBIgene178970
RefSeqproteinNM_072122.6
SwissProtUniProtAccG5EBZ4
TREEFAMTREEFAM_IDTF300674
UniProt_GCRPUniProtAccG5EBZ4
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:28WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlet
Reference_alleleWBVar00242167
Allele (88)
Legacy_informationSterile adult
See also s1045, s1617
[C.elegansII] s1617 : sterile adult, Evl, partial rescue 15C.OA1: s1045 (sterile Evl adult 24C, Mel (early larval lethal) at 20C). [Johnsen and Baillie 1991; BC]
[C.elegansII] ar114 : everted vulva, sterile; abnormal L4 vulval invagination; no uterine cavity; abnormal oocytes. OA1: ar113 (similar). [Seydoux et al., 1993]
StrainWBStrain00027456
WBStrain00000738
WBStrain00008003
WBStrain00008004
WBStrain00034737
RNASeq_FPKM (74)
GO_annotation (28)
Contained_in_operonCEOP5547
OrthologWBGene00058869Caenorhabditis remaneiFrom_analysisOMA
Inparanoid_8
WormBase-Compara
WBGene00030916Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00150229Caenorhabditis brenneriFrom_analysisOMA
Inparanoid_8
WormBase-Compara
WBGene00141711Caenorhabditis brenneriFrom_analysisTreeFam
WBGene00158067Caenorhabditis brenneriFrom_analysisTreeFam
WBGene00139645Caenorhabditis brenneriFrom_analysisTreeFam
WBGene00120547Caenorhabditis japonicaFrom_analysisTreeFam
WBGene00194188Caenorhabditis brenneriFrom_analysisInparanoid_8
WormBase-Compara
WBGene00223894Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g7328Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g7073Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g903Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g15743Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g14265Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g247Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g15183Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g6497Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g25902Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g28444Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g3021Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g24578Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00828.g14426Caenorhabditis angariaFrom_analysisWormBase-Compara
Cang_2012_03_13_08632.g21619Caenorhabditis angariaFrom_analysisWormBase-Compara
Cnig_chr_V.g19723Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold536.g3282Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_01151.g18789Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_21722Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_017812Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g08630Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g6670Panagrellus redivivusFrom_analysisWormBase-Compara
chrV_pilon.g14321Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00184625Caenorhabditis japonicaFrom_analysisWormBase-Compara
WBGene00246735Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00283833Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00258367Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00264941Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00296929Trichuris murisFrom_analysisWormBase-Compara
WBGene00302135Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0023395Drosophila melanogasterFrom_analysisEnsEMBL-Compara
OrthoFinder
Panther
PhylomeDB
FB:FBgn0262519Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-120314-2Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-041111-187Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-030131-4532Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-121031-4Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
HGNC:1918Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:1919Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:16816Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1344380Mus musculusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1344395Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:3036258Mus musculusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:620064Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:1311923Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1582725Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
Paralog (19)
Structured_descriptionConcise_descriptionThe let-418 gene encodes a homolog of Mi-2/CHD3, a component of the nucleosome remodeling and histone deacetylase (NURD) complex; LET-418 is similar to DNA helicases, homologous to human AIRE (OMIM:607358, mutated in autoimmune polyendocrinopathy syndrome), and paralogous to CHD-3; with MEP-1, LET-418 is required to repress germline-specific genes in somatic cells, and also negatively regulates RAS-dependent postembryonic vulval development (via the synMuvB pathway); LET-418 and CHD-3 are redundantly required for specification of secondary cell fates in vulval development; LET-418 is expressed in all interphase nuclei throughout development; LET-418 is bound by MEP-1, and also interacts with HDA-1 and PIE-1; these interactions probably reflect repression of LET-418 by PIE-1 in the germline.Paper_evidenceWBPaper00004103
WBPaper00004491
WBPaper00005605
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic digestive tract morphogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vulval development. Part of RNA polymerase II transcription repressor complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; gonad; and somatic nervous system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung adenocarcinoma; and lymphoma. Is an ortholog of human CHD3 (chromodomain helicase DNA binding protein 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1919)
DOID:1993Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1919)
DOID:3910Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1919)
DOID:1324Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1919)
DOID:234Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1919)
DOID:0060058Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1919)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16816,HGNC:1919)
Molecular_infoCorresponding_CDSF26F12.7
Corresponding_transcriptF26F12.7.1
Other_sequence (73)
Associated_feature (13)
Transcription_factorWBTranscriptionFactor000465
Experimental_infoRNAi_result (19)
Expr_patternChronogram1802
Expr1045
Expr5876
Expr9222
Expr1013785
Expr1031359
Expr1149567
Expr1200190
Expr2013058
Expr2031290
Drives_constructWBCnstr00003430
WBCnstr00010046
WBCnstr00013808
WBCnstr00036324
WBCnstr00038091
Construct_productWBCnstr00036324
WBCnstr00038091
Regulate_expr_cluster (14)
AntibodyWBAntibody00000593
WBAntibody00001250
WBAntibody00001251
WBAntibody00002740
Microarray_results (19)
Expression_cluster (166)
Interaction (139)
Map_infoMapVPosition-0.814163Error0.000556
Well_ordered
PositivePositive_cloneF26F12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point3492
3493
3494
3495
4567
Pos_neg_data3417
3423
3514
3515
3516
3517
3518
4337
5821
Landmark_gene
Reference (103)
MethodGene