WormBase Tree Display for Gene: WBGene00002637
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| WBGene00002637 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F26F12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | let-418 | Person_evidence | WBPerson533 | |||||
| Sequence_name | F26F12.7 | ||||||||
| Molecular_name | F26F12.7 | ||||||||
| F26F12.7.1 | |||||||||
| CE17716 | |||||||||
| Other_name | evl-11 | ||||||||
| chd-4 | |||||||||
| CELE_F26F12.7 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | let-418 | ||||||||
| DB_info | Database | AceView | gene | 5G311 | |||||
| WormQTL | gene | WBGene00002637 | |||||||
| WormFlux | gene | WBGene00002637 | |||||||
| NDB | locus_tag | CELE_F26F12.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002637|UniProtKB=G5EBZ4 | |||||||
| family | PTHR45623 | ||||||||
| NCBI | gene | 178970 | |||||||
| RefSeq | protein | NM_072122.6 | |||||||
| SwissProt | UniProtAcc | G5EBZ4 | |||||||
| TREEFAM | TREEFAM_ID | TF300674 | |||||||
| UniProt_GCRP | UniProtAcc | G5EBZ4 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:28 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | let | ||||||||
| Reference_allele | WBVar00242167 | ||||||||
| Allele (88) | |||||||||
| Legacy_information | Sterile adult | ||||||||
| See also s1045, s1617 | |||||||||
| [C.elegansII] s1617 : sterile adult, Evl, partial rescue 15C.OA1: s1045 (sterile Evl adult 24C, Mel (early larval lethal) at 20C). [Johnsen and Baillie 1991; BC] | |||||||||
| [C.elegansII] ar114 : everted vulva, sterile; abnormal L4 vulval invagination; no uterine cavity; abnormal oocytes. OA1: ar113 (similar). [Seydoux et al., 1993] | |||||||||
| Strain | WBStrain00027456 | ||||||||
| WBStrain00000738 | |||||||||
| WBStrain00008003 | |||||||||
| WBStrain00008004 | |||||||||
| WBStrain00034737 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP5547 | ||||||||
| Ortholog (53) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | The let-418 gene encodes a homolog of Mi-2/CHD3, a component of the nucleosome remodeling and histone deacetylase (NURD) complex; LET-418 is similar to DNA helicases, homologous to human AIRE (OMIM:607358, mutated in autoimmune polyendocrinopathy syndrome), and paralogous to CHD-3; with MEP-1, LET-418 is required to repress germline-specific genes in somatic cells, and also negatively regulates RAS-dependent postembryonic vulval development (via the synMuvB pathway); LET-418 and CHD-3 are redundantly required for specification of secondary cell fates in vulval development; LET-418 is expressed in all interphase nuclei throughout development; LET-418 is bound by MEP-1, and also interacts with HDA-1 and PIE-1; these interactions probably reflect repression of LET-418 by PIE-1 in the germline. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00004491 | |||||||||
| WBPaper00005605 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic digestive tract morphogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vulval development. Part of RNA polymerase II transcription repressor complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; gonad; and somatic nervous system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung adenocarcinoma; and lymphoma. Is an ortholog of human CHD3 (chromodomain helicase DNA binding protein 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1919) | ||||
| DOID:1993 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1919) | ||||||
| DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1919) | ||||||
| DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1919) | ||||||
| DOID:234 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1919) | ||||||
| DOID:0060058 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1919) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16816,HGNC:1919) | ||||||
| Molecular_info | Corresponding_CDS | F26F12.7 | |||||||
| Corresponding_transcript | F26F12.7.1 | ||||||||
| Other_sequence (73) | |||||||||
| Associated_feature (13) | |||||||||
| Transcription_factor | WBTranscriptionFactor000465 | ||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Chronogram1802 | ||||||||
| Expr1045 | |||||||||
| Expr5876 | |||||||||
| Expr9222 | |||||||||
| Expr1013785 | |||||||||
| Expr1031359 | |||||||||
| Expr1149567 | |||||||||
| Expr1200190 | |||||||||
| Expr2013058 | |||||||||
| Expr2031290 | |||||||||
| Drives_construct | WBCnstr00003430 | ||||||||
| WBCnstr00010046 | |||||||||
| WBCnstr00013808 | |||||||||
| WBCnstr00036324 | |||||||||
| WBCnstr00038091 | |||||||||
| Construct_product | WBCnstr00036324 | ||||||||
| WBCnstr00038091 | |||||||||
| Regulate_expr_cluster (14) | |||||||||
| Antibody | WBAntibody00000593 | ||||||||
| WBAntibody00001250 | |||||||||
| WBAntibody00001251 | |||||||||
| WBAntibody00002740 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (166) | |||||||||
| Interaction (139) | |||||||||
| Map_info | Map | V | Position | -0.814163 | Error | 0.000556 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F26F12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3492 | |||||||
| 3493 | |||||||||
| 3494 | |||||||||
| 3495 | |||||||||
| 4567 | |||||||||
| Pos_neg_data | 3417 | ||||||||
| 3423 | |||||||||
| 3514 | |||||||||
| 3515 | |||||||||
| 3516 | |||||||||
| 3517 | |||||||||
| 3518 | |||||||||
| 4337 | |||||||||
| 5821 | |||||||||
| Landmark_gene | |||||||||
| Reference (103) | |||||||||
| Method | Gene |
