WormBase Tree Display for Gene: WBGene00002173
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WBGene00002173 | SMap | S_parent | Sequence | F33D4 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | itr | ||||||
Allele (221) | |||||||
Legacy_information | [C.elegansII] NMK. Sequence (yk33g8) has similarity to receptor for inositol 1,4,5 trisphosphate from vertebrates and Drosophila [CGC] | ||||||
[Clandinin T] mutations suppress let-23 sterility | |||||||
[C.elegansII] sy290 : suppresses sterility of let-23 mutations. [PS] | |||||||
[Dal Santo P] sa73:(weak allele),long defecation cycle time,constipated, reducedbrood size | |||||||
[Dal Santo P] n2559 (strong allele):no defecation cycle, severely constipated, slow growth, steril | |||||||
[Dal Santo P] DalSanto et al. 1999. The inositol trisphosphate receptor regulates a 50-secondbehavioral rhythm in C. elegans. Cell, in press | |||||||
[Baylis H] itr for Inositol Trisphosphate Receptor family. Sequence has similarity to receptor for inositol 1,4,5 trisphosphate from vertebrates and Drosophila | |||||||
[Thomas JH] long defecation cycle period, slightly slow growing and scrawny, reduced brood especially at 25C. appears to feed normally | |||||||
[C.elegansII] sa73 : long defecation cycle period, slightly slow growing and scrawny, reduced brood especially at 25C; appears to feed normally. [Iwasaki et al. 1995; JT] | |||||||
Strain (11) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (53) | |||||||
Ortholog (54) | |||||||
Paralog | WBGene00006801 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | itr-1 encodes a putative inositol (1,4,5) trisphosphate receptor that affects the defecation cycle and pharyngeal pumping, and also affects ovulation in a pathway downstream of LET-23; interacts with UNC-54 in vivo, and is expressed in the adult intestine, pharynx, excretory cell, germ line, and spermatheca, with limited neuronal expression. | Paper_evidence | WBPaper00002315 | |||
WBPaper00003017 | |||||||
WBPaper00003239 | |||||||
WBPaper00003693 | |||||||
WBPaper00003819 | |||||||
WBPaper00004858 | |||||||
WBPaper00005235 | |||||||
WBPaper00005268 | |||||||
WBPaper00005299 | |||||||
Curator_confirmed | WBPerson48 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; multicellular organism reproduction; and system process. Located in endoplasmic reticulum and membrane. Expressed in several structures, including egg-laying apparatus; ganglia; gonad; non-striated muscle; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Gillespie syndrome; and isolated anhidrosis with normal sweat glands. Is an ortholog of human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (11) | ||||||
Molecular_info | Corresponding_CDS | F33D4.2a | |||||
F33D4.2d | |||||||
F33D4.2e | |||||||
F33D4.2f | |||||||
F33D4.2g | |||||||
F33D4.2h | |||||||
Corresponding_CDS_history | F33D4.2a:wp137 | ||||||
F33D4.2b:wp53 | |||||||
F33D4.2c:wp137 | |||||||
F33D4.2d:wp137 | |||||||
Corresponding_transcript | F33D4.2a.1 | ||||||
F33D4.2d.1 | |||||||
F33D4.2e.1 | |||||||
F33D4.2f.1 | |||||||
F33D4.2g.1 | |||||||
F33D4.2h.1 | |||||||
Other_sequence (69) | |||||||
Associated_feature (18) | |||||||
Experimental_info | RNAi_result (50) | ||||||
Expr_pattern (14) | |||||||
Drives_construct (68) | |||||||
Construct_product | WBCnstr00011613 | ||||||
WBCnstr00013218 | |||||||
WBCnstr00013225 | |||||||
WBCnstr00013234 | |||||||
WBCnstr00036410 | |||||||
Antibody | WBAntibody00000255 | ||||||
WBAntibody00001608 | |||||||
Microarray_results (62) | |||||||
Expression_cluster (185) | |||||||
Interaction (140) | |||||||
WBProcess | WBbiopr:00000010 | ||||||
WBbiopr:00000067 | |||||||
Map_info | Map | IV | Position | 3.3765 | Error | 0.003586 | |
Well_ordered | |||||||
Positive | Positive_clone | F33D4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
R06H2 | Person_evidence | WBPerson51 | |||||
Author_evidence | Dal Santo P | ||||||
Mapping_data | Multi_point | 3909 | |||||
3249 | |||||||
3250 | |||||||
3251 | |||||||
4520 | |||||||
5633 | |||||||
Reference (170) | |||||||
Remark | data from H Baylis, University of Cambridge | ||||||
data from paola@howard.genetics.utah.edu | |||||||
Method | Gene |