WormBase Tree Display for Gene: WBGene00002173
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WBGene00002173 | SMap | S_parent | Sequence | F33D4 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | itr-1 | Person_evidence | WBPerson1430 | |||||
Sequence_name | F33D4.2 | ||||||||
Molecular_name (18) | |||||||||
Other_name | lfe-1 | ||||||||
dec-4 | CGC_data_submission | ||||||||
CELE_F33D4.2 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | itr-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | itr | ||||||||
Allele (221) | |||||||||
Legacy_information | [C.elegansII] NMK. Sequence (yk33g8) has similarity to receptor for inositol 1,4,5 trisphosphate from vertebrates and Drosophila [CGC] | ||||||||
[Clandinin T] mutations suppress let-23 sterility | |||||||||
[C.elegansII] sy290 : suppresses sterility of let-23 mutations. [PS] | |||||||||
[Dal Santo P] sa73:(weak allele),long defecation cycle time,constipated, reducedbrood size | |||||||||
[Dal Santo P] n2559 (strong allele):no defecation cycle, severely constipated, slow growth, steril | |||||||||
[Dal Santo P] DalSanto et al. 1999. The inositol trisphosphate receptor regulates a 50-secondbehavioral rhythm in C. elegans. Cell, in press | |||||||||
[Baylis H] itr for Inositol Trisphosphate Receptor family. Sequence has similarity to receptor for inositol 1,4,5 trisphosphate from vertebrates and Drosophila | |||||||||
[Thomas JH] long defecation cycle period, slightly slow growing and scrawny, reduced brood especially at 25C. appears to feed normally | |||||||||
[C.elegansII] sa73 : long defecation cycle period, slightly slow growing and scrawny, reduced brood especially at 25C; appears to feed normally. [Iwasaki et al. 1995; JT] | |||||||||
Strain (11) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (53) | |||||||||
Ortholog (54) | |||||||||
Paralog | WBGene00006801 | Caenorhabditis elegans | From_analysis (2) | ||||||
Structured_description | Concise_description | itr-1 encodes a putative inositol (1,4,5) trisphosphate receptor that affects the defecation cycle and pharyngeal pumping, and also affects ovulation in a pathway downstream of LET-23; interacts with UNC-54 in vivo, and is expressed in the adult intestine, pharynx, excretory cell, germ line, and spermatheca, with limited neuronal expression. | Paper_evidence | WBPaper00002315 | |||||
WBPaper00003017 | |||||||||
WBPaper00003239 | |||||||||
WBPaper00003693 | |||||||||
WBPaper00003819 | |||||||||
WBPaper00004858 | |||||||||
WBPaper00005235 | |||||||||
WBPaper00005268 | |||||||||
WBPaper00005299 | |||||||||
Curator_confirmed | WBPerson48 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; multicellular organism reproduction; and system process. Located in endoplasmic reticulum and membrane. Expressed in several structures, including egg-laying apparatus; ganglia; gonad; non-striated muscle; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Gillespie syndrome; and isolated anhidrosis with normal sweat glands. Is an ortholog of human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (11) | ||||||||
Molecular_info | Corresponding_CDS | F33D4.2a | |||||||
F33D4.2d | |||||||||
F33D4.2e | |||||||||
F33D4.2f | |||||||||
F33D4.2g | |||||||||
F33D4.2h | |||||||||
Corresponding_CDS_history | F33D4.2a:wp137 | ||||||||
F33D4.2b:wp53 | |||||||||
F33D4.2c:wp137 | |||||||||
F33D4.2d:wp137 | |||||||||
Corresponding_transcript | F33D4.2a.1 | ||||||||
F33D4.2d.1 | |||||||||
F33D4.2e.1 | |||||||||
F33D4.2f.1 | |||||||||
F33D4.2g.1 | |||||||||
F33D4.2h.1 | |||||||||
Other_sequence (69) | |||||||||
Associated_feature (18) | |||||||||
Experimental_info | RNAi_result (50) | ||||||||
Expr_pattern (14) | |||||||||
Drives_construct (68) | |||||||||
Construct_product | WBCnstr00011613 | ||||||||
WBCnstr00013218 | |||||||||
WBCnstr00013225 | |||||||||
WBCnstr00013234 | |||||||||
WBCnstr00036410 | |||||||||
Antibody | WBAntibody00000255 | ||||||||
WBAntibody00001608 | |||||||||
Microarray_results (62) | |||||||||
Expression_cluster (185) | |||||||||
Interaction (140) | |||||||||
WBProcess | WBbiopr:00000010 | ||||||||
WBbiopr:00000067 | |||||||||
Map_info | Map | IV | Position | 3.3765 | Error | 0.003586 | |||
Well_ordered | |||||||||
Positive | Positive_clone | F33D4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
R06H2 | Person_evidence | WBPerson51 | |||||||
Author_evidence | Dal Santo P | ||||||||
Mapping_data | Multi_point | 3909 | |||||||
3249 | |||||||||
3250 | |||||||||
3251 | |||||||||
4520 | |||||||||
5633 | |||||||||
Reference (170) | |||||||||
Remark | data from H Baylis, University of Cambridge | ||||||||
data from paola@howard.genetics.utah.edu | |||||||||
Method | Gene |