WormBase Tree Display for Gene: WBGene00001580

WBGene00001580 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 1
    Name: CGC_name: gex-3 Person_evidence: WBPerson419
      Sequence_name: F28D1.10
      Molecular_name: F28D1.10
        F28D1.10.1
        CE05750
      Other_name: CELE_F28D1.10 Accession_evidence: NDB BX284604
      Public_name: gex-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gex
    Allele (48)
    Strain: WBStrain00040419
      WBStrain00024269
      WBStrain00051117
      WBStrain00055525
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog (44)
    Structured_description: Concise_description: The gex-3 gene encodes a homolog of NAP1/NCKAP1, a mammalian protein ligand of the small GTPase Rac1, and of Drosophila HEM2/NAP1/KETTE; gex-3 is required for tissue morphogenesis and cell migrations; in gex-3 mutants, cells differentiate properly but fail to become organized. Paper_evidence: WBPaper00005149
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Involved in several processes, including egg-laying behavior; embryonic morphogenesis; and positive regulation of cellular component organization. Located in cell junction. Part of SCAR complex. Expressed in intestinal cell. Human ortholog(s) of this gene implicated in immunodeficiency 72. Is an ortholog of human NCKAP1 (NCK associated protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112015 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4862)
  Molecular_info: Corresponding_CDS: F28D1.10
    Corresponding_transcript: F28D1.10.1
    Other_sequence (40)
    Associated_feature: WBsf646473
      WBsf229287
      WBsf229288
  Experimental_info: RNAi_result (41)
    Expr_pattern: Expr1828
      Expr8395
      Expr10794
      Expr12485
      Expr1017668
      Expr1030946
      Expr1149732
      Expr2012024
      Expr2030260
    Drives_construct: WBCnstr00013296
      WBCnstr00036848
    Construct_product: WBCnstr00009364
      WBCnstr00013296
      WBCnstr00017546
      WBCnstr00036848
    Antibody: WBAntibody00000464
    Microarray_results (22)
    Expression_cluster (120)
    Interaction: WBInteraction000006170
      WBInteraction000006208
      WBInteraction000006239
      WBInteraction000006354
      WBInteraction000009181
      WBInteraction000032605
      WBInteraction000033109
      WBInteraction000033110
      WBInteraction000033111
      WBInteraction000033287
      WBInteraction000033411
      WBInteraction000033962
      WBInteraction000041846
      WBInteraction000041847
      WBInteraction000041848
      WBInteraction000042670
      WBInteraction000043394
      WBInteraction000043966
      WBInteraction000047228
      WBInteraction000048534
      WBInteraction000048808
      WBInteraction000048822
      WBInteraction000049108
      WBInteraction000049479
      WBInteraction000051766
      WBInteraction000051769
      WBInteraction000135535
      WBInteraction000157334
      WBInteraction000158061
      WBInteraction000158062
      WBInteraction000158063
      WBInteraction000158064
      WBInteraction000158065
      WBInteraction000158435
      WBInteraction000167050
      WBInteraction000167148
      WBInteraction000167149
      WBInteraction000169399
      WBInteraction000283703
      WBInteraction000284203
      WBInteraction000312900
      WBInteraction000317877
      WBInteraction000354656
      WBInteraction000374852
      WBInteraction000394655
      WBInteraction000396311
      WBInteraction000401918
      WBInteraction000401921
      WBInteraction000421832
      WBInteraction000425616
      WBInteraction000425632
      WBInteraction000439699
      WBInteraction000503822
      WBInteraction000503823
      WBInteraction000503824
      WBInteraction000503826
      WBInteraction000504989
      WBInteraction000519887
      WBInteraction000519890
      WBInteraction000519891
      WBInteraction000519892
      WBInteraction000519893
      WBInteraction000519894
      WBInteraction000519895
      WBInteraction000520177
      WBInteraction000535532
      WBInteraction000536177
      WBInteraction000536179
      WBInteraction000541404
      WBInteraction000550384
      WBInteraction000550385
      WBInteraction000550386
      WBInteraction000550387
      WBInteraction000550388
      WBInteraction000550389
      WBInteraction000550390
      WBInteraction000550391
      WBInteraction000550392
      WBInteraction000550393
      WBInteraction000550394
      WBInteraction000550395
      WBInteraction000550396
      WBInteraction000550397
      WBInteraction000550398
      WBInteraction000550399
      WBInteraction000550400
      WBInteraction000550401
      WBInteraction000550402
      WBInteraction000550403
      WBInteraction000550404
      WBInteraction000550405
      WBInteraction000550406
      WBInteraction000550407
      WBInteraction000550408
      WBInteraction000550409
      WBInteraction000556197
      WBInteraction000556413
      WBInteraction000556414
      WBInteraction000571576
      WBInteraction000571577
  Map_info: Positive: Positive_clone: F28D1 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4816
    Interpolated_map_position: IV 5.91283
  Reference (37)
  Remark: most on F28D1.10; the 3' end on F08G5 (nucleotides 1 to 4576). predicted gene previously called CeHEM2; mammalian homolog is called HEM2 and NAP1, and the fly homolog is called KETTE. [Soto M]
  Method: Gene