WormBase Tree Display for Gene: WBGene00001377
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| WBGene00001377 | Evidence | Person_evidence | WBPerson634 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C49A1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | eya-1 | Person_evidence | WBPerson634 | |||||
| Sequence_name | C49A1.4 | ||||||||
| Molecular_name | C49A1.4a | ||||||||
| C49A1.4a.1 | |||||||||
| CE36113 | |||||||||
| C49A1.4b | |||||||||
| CE15722 | |||||||||
| C49A1.4b.1 | |||||||||
| C49A1.4b.2 | |||||||||
| C49A1.4b.3 | |||||||||
| Other_name | CELE_C49A1.4 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | eya-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | eya | ||||||||
| Allele (203) | |||||||||
| Strain | WBStrain00033881 | ||||||||
| WBStrain00033887 | |||||||||
| WBStrain00035846 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (55) | |||||||||
| Ortholog (45) | |||||||||
| Structured_description | Concise_description | eya-1 encodes a protein orthologous to the Eyes absent/Eya Drosophila protein which is involved in eye development and has protein tyrosine phosphatase ; RNA interference and mutant studies indicate that eya-1 is involved in embryonic and larval tissue morphogenesis as well as larval viability; eya-1 mutants show increased embryonic cell deaths due to activation of the cell death pathway; eya-1 functions redundantly with vab-3/eyeless to control larval viability and anterior body morphogenesis; GFP studies show that eya-1 is expressed in a subset of nuclei during embryonic morphogenesis; the human genes EYA1 and EYA4, when mutated, lead to disease syndromes. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00026796 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 01 Aug 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein tyrosine phosphatase activity and transcription coactivator activity. Involved in several processes, including egg-laying behavior; positive regulation of cellular response to heat; and regulation of apoptotic process. Located in nucleus. Expressed in several structures, including body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); branchiootorenal syndrome 1; and dilated cardiomyopathy 1J. Is an ortholog of several human genes including EYA1 (EYA transcriptional coactivator and phosphatase 1); EYA2 (EYA transcriptional coactivator and phosphatase 2); and EYA4 (EYA transcriptional coactivator and phosphatase 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:699 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3519) | ||||
| DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3522) | ||||||
| DOID:14702 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3519) | ||||||
| DOID:0111423 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3519) | ||||||
| DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3522) | ||||||
| DOID:0110440 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3522) | ||||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3522) | ||||||
| DOID:0110542 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3522) | ||||||
| Molecular_info | Corresponding_CDS | C49A1.4a | |||||||
| C49A1.4b | |||||||||
| Corresponding_CDS_history | C49A1.4:wp114 | ||||||||
| Corresponding_transcript | C49A1.4a.1 | ||||||||
| C49A1.4b.1 | |||||||||
| C49A1.4b.2 | |||||||||
| C49A1.4b.3 | |||||||||
| Other_sequence | GT571535.1 | ||||||||
| Oden_isotig19690 | |||||||||
| GT571108.1 | |||||||||
| HG09694 | |||||||||
| MH07118 | |||||||||
| PT01133 | |||||||||
| MJ01224 | |||||||||
| JI460669.1 | |||||||||
| HGC05778_1 | |||||||||
| GT570770.1 | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00042756 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00063936 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063937 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063935 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029954 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063938 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063939 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3777 | ||||||||
| Expr5536 | |||||||||
| Expr14291 | |||||||||
| Expr16094 | |||||||||
| Expr1027245 | |||||||||
| Expr1030829 | |||||||||
| Expr1146744 | |||||||||
| Expr2011410 | |||||||||
| Expr2029646 | |||||||||
| Drives_construct | WBCnstr00003404 | ||||||||
| WBCnstr00004723 | |||||||||
| WBCnstr00007531 | |||||||||
| WBCnstr00007580 | |||||||||
| WBCnstr00007581 | |||||||||
| Construct_product | WBCnstr00004723 | ||||||||
| WBCnstr00006029 | |||||||||
| WBCnstr00006030 | |||||||||
| WBCnstr00007531 | |||||||||
| WBCnstr00007580 | |||||||||
| WBCnstr00007581 | |||||||||
| Antibody | WBAntibody00002547 | ||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (185) | |||||||||
| Interaction (594) | |||||||||
| Map_info | Map | I | Position | 23.8881 | Error | 0.07657 | |||
| Positive | Positive_clone | C49A1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4793 | |||||||
| 4572 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
