WormBase Tree Display for Gene: WBGene00001340

WBGene00001340 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: etr-1 Person_evidence: WBPerson261
      Sequence_name: T01D1.2
      Molecular_name (70)
      Other_name: CELE_T01D1.2 Accession_evidence: NDB BX284602
      Public_name: etr-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: etr
    Allele (130)
    Possibly_affected_by: WBVar02152955
      WBVar02152954
    Strain: WBStrain00054854
      WBStrain00054853
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (43)
    Paralog (13)
    Structured_description: Concise_description: etr-1 encodes a muscle-specific ELAV-type RNA-binding protein, whose homologs include Drosophila ELAV and human CUG-BINDING PROTEIN (CUGBP1; OMIM:601074); etr-1 function is required for embryonic muscle development, which suggests that ETR-1's homology to CUG-BP (implicated in myotonic dystrophy) might reflect conserved roles in development. Paper_evidence: WBPaper00003747
            WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable mRNA 3'-UTR binding activity. Involved in determination of adult lifespan. Located in nucleus. Expressed in body wall musculature; cloacal sphincter muscle; copulatory spicule; non-striated muscle; and somatic gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Is an ortholog of human CELF1 (CUGBP Elav-like family member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070383 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2550)
  Molecular_info: Corresponding_CDS (19)
    Corresponding_CDS_history: T01D1.2b:wp182
      T01D1.2c:wp247
    Corresponding_transcript (32)
    Other_sequence (57)
    Associated_feature (19)
  Experimental_info: RNAi_result (25)
    Expr_pattern: Expr1204
      Expr9488
      Expr13464
      Expr1026122
      Expr1030819
      Expr1155747
      Expr2011378
      Expr2029614
    Drives_construct: WBCnstr00010149
      WBCnstr00036992
    Construct_product: WBCnstr00014053
      WBCnstr00036992
    Regulate_expr_cluster: WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062325:muscle_depleted_noncoding-RNA
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062325:muscle_enriched_noncoding-RNA
    Antibody: WBAntibody00002767
    Microarray_results: SMD_T01D1.2
      172031_x_at
      174097_at
      192227_s_at
      A_12_P120167
      A_12_P152070
      A_12_P152071
      A_12_P152072
      A_12_P152073
      A_12_P152074
      A_12_P153655
      A_12_P153656
      A_12_P153657
      A_12_P153658
      Aff_T01D1.2A
      GPL13394_WBGene00001340
      GPL13914_T01D1.2
      GPL14144_T01D1.2f_1543-1602_0.947_2_B
      GPL14144_T01D1.2f_1602-1661_0.936_4_C
      GPL14144_T01D1.2f_1720-1779_0.958_1_A
      GPL19516_CGZ0032610
      GPL19516_CGZ0032611
      GPL19516_CGZ0032612
      GPL19516_CGZ0032613
      GPL19516_CGZ0032614
      GPL19516_CGZ0032615
      GPL19516_CGZ0032616
      GPL19516_CGZ0032617
      GPL19516_CGZ0032618
      GPL19516_CGZ0032619
      GPL19516_CGZ0032620
      GPL19516_CGZ0032621
      GPL19516_CGZ0032622
      GPL19516_CGZ0032623
      GPL19516_CGZ0032624
      GPL19516_CGZ0032625
      GPL19516_CGZ0032626
      GPL19516_CGZ0032627
      GPL19516_CGZ0032628
      GPL19516_CGZ0032629
      GPL19516_CGZ0032630
      GPL19516_CGZ0032631
      GPL19516_CGZ0032632
      GPL19516_CGZ0032633
      GPL19516_CGZ0032634
      GPL19516_CGZ0032635
      GPL19516_CGZ0032636
      GPL19516_CGZ0032637
      GPL19516_CGZ0032638
      GPL19516_CGZ0032639
      GPL19516_CGZ0032640
      GPL21109_T01D1.2a.1
      GPL21109_T01D1.2a.2
      GPL21109_T01D1.2a.3
      GPL21109_T01D1.2e.4
      GPL3518_CE12942
      GPL3518_CE28070
      GPL8304_CE_WBGene00001340_A
      GPL8304_CE_WBGene00001340_B
      GPL8304_CE_WBGene00001340_C
      GPL8673_T01D1_2aP00255
      GPL8673_T01D1_2aP00894
      GPL8673_T01D1_2aP00904
      GPL8673_T01D1_2bP00552
      GPL8673_T01D1_2bP00704
      GPL8673_T01D1_2bP00718
      GPL8673_T01D1_2cP00006
      GPL8673_T01D1_2cP00075
      GPL8673_T01D1_2cP00133
      GPL9450_T01D1.2a
      GPL9450_T01D1.2b
      cea2.3.22250
      cea2.d.05181
      cea2.d.05182
    Expression_cluster (115)
    Interaction (42)
  Map_info: Map: II Position: -15.9026 Error: 0.013546
    Positive: Positive_clone: T01D1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (23)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene