WormBase Tree Display for Gene: WBGene00001340

WBGene00001340 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: etr-1 Person_evidence: WBPerson261
      Sequence_name: T01D1.2
      Molecular_name (70)
      Other_name: CELE_T01D1.2 Accession_evidence: NDB BX284602
      Public_name: etr-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: etr
    Allele (130)
    Possibly_affected_by: WBVar02152955
      WBVar02152954
    Strain: WBStrain00054854
      WBStrain00054853
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (43)
    Paralog (13)
    Structured_description: Concise_description: etr-1 encodes a muscle-specific ELAV-type RNA-binding protein, whose homologs include Drosophila ELAV and human CUG-BINDING PROTEIN (CUGBP1; OMIM:601074); etr-1 function is required for embryonic muscle development, which suggests that ETR-1's homology to CUG-BP (implicated in myotonic dystrophy) might reflect conserved roles in development. Paper_evidence: WBPaper00003747
            WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable mRNA 3'-UTR binding activity. Involved in determination of adult lifespan. Located in nucleus. Expressed in body wall musculature; cloacal sphincter muscle; copulatory spicule; non-striated muscle; and somatic gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Is an ortholog of human CELF1 (CUGBP Elav-like family member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070383 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2550)
  Molecular_info: Corresponding_CDS (19)
    Corresponding_CDS_history: T01D1.2b:wp182
      T01D1.2c:wp247
    Corresponding_transcript (32)
    Other_sequence (57)
    Associated_feature (19)
  Experimental_info: RNAi_result (25)
    Expr_pattern: Expr1204
      Expr9488
      Expr13464
      Expr1026122
      Expr1030819
      Expr1155747
      Expr2011378
      Expr2029614
    Drives_construct: WBCnstr00010149
      WBCnstr00036992
    Construct_product: WBCnstr00014053
      WBCnstr00036992
    Regulate_expr_cluster: WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062325:muscle_depleted_noncoding-RNA
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062325:muscle_enriched_noncoding-RNA
    Antibody: WBAntibody00002767
    Microarray_results (74)
    Expression_cluster (115)
    Interaction: WBInteraction000009621
      WBInteraction000028533
      WBInteraction000030483
      WBInteraction000034196
      WBInteraction000034279
      WBInteraction000035940
      WBInteraction000036350
      WBInteraction000037185
      WBInteraction000037944
      WBInteraction000039206
      WBInteraction000039696
      WBInteraction000039697
      WBInteraction000040930
      WBInteraction000041411
      WBInteraction000043904
      WBInteraction000045200
      WBInteraction000045238
      WBInteraction000046790
      WBInteraction000047431
      WBInteraction000048449
      WBInteraction000049031
      WBInteraction000227685
      WBInteraction000242147
      WBInteraction000258315
      WBInteraction000281236
      WBInteraction000287475
      WBInteraction000298578
      WBInteraction000353051
      WBInteraction000364537
      WBInteraction000373928
      WBInteraction000389116
      WBInteraction000392932
      WBInteraction000398618
      WBInteraction000437133
      WBInteraction000438972
      WBInteraction000511567
      WBInteraction000514453
      WBInteraction000514462
      WBInteraction000519814
      WBInteraction000548612
      WBInteraction000574883
      WBInteraction000582230
  Map_info: Map: II Position: -15.9026 Error: 0.013546
    Positive: Positive_clone: T01D1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (23)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene