| WBGene00001131 | SMap | S_parent | Sequence | CHROMOSOME_I |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | dys-1 | Person_evidence | WBPerson571 |
| | | Sequence_name | F15D3.1 |
| | | Molecular_name (30) |
| | | Other_name | CELE_F15D3.1 | Accession_evidence | NDB | BX284601 |
| | | Public_name | dys-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | dys |
| | Allele (647) |
| | Possibly_affected_by | WBVar02153522 |
| | Strain | WBStrain00002611 |
| | | WBStrain00024335 |
| | | WBStrain00024340 |
| | | WBStrain00024342 |
| | | WBStrain00024343 |
| | | WBStrain00037736 |
| | | WBStrain00004037 |
| | | WBStrain00048693 |
| | RNASeq_FPKM (74) |
| | GO_annotation (37) |
| | Ortholog (37) |
| | Structured_description | Concise_description | The dys-1 gene encodes an ortholog of human DMD, which when mutated leads to Duchenne muscular dystrophy (OMIM:310200). | Paper_evidence | WBPaper00004103 |
| | | | | | WBPaper00005175 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable actin binding activity and zinc ion binding activity. Involved in several processes, including forward locomotion; muscle cell cellular homeostasis; and sarcomere organization. Located in striated muscle dense body. Part of dystrobrevin complex. Expressed in body wall musculature; head muscle; pharyngeal muscle cell; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in several diseases, including Becker muscular dystrophy; Duchenne muscular dystrophy; cognitive disorder; dilated cardiomyopathy (multiple); and ovarian cancer. Is an ortholog of human DMD (dystrophin) and UTRN (utrophin). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:11723 | Homo sapiens | Paper_evidence | WBPaper00003867 |
| | | | | | WBPaper00003395 |
| | | | | | WBPaper00044415 |
| | | | | | WBPaper00035094 |
| | | | | Accession_evidence | OMIM | 300376 |
| | | | | | | 310200 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 22 May 2017 00:00:00 |
| | Potential_model | DOID:11723 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2928) |
| | | DOID:0081164 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2928) |
| | | DOID:1561 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2928) |
| | | DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12635) |
| | | DOID:0110461 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2928) |
| | | DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2928) |
| | | DOID:1059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2928) |
| | | DOID:9883 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2928) |
| | Disease_relevance | Mutations in human dystrophin are associated with the Duchenne and Becker types of muscular dystrophy, that affect skeletal muscles used for movement, and heart (cardiac) muscle; in C. elegans, loss-of-function mutants in dys-1 (cx18,cx26,cx35,cx40), the ortholog of human dystrophin/utrophin, display locomotion defects like hyperactivity and hypercontraction, and are hypersensitive to acetylcholine and to the acetylcholinesterase inhibitor, aldicarb, suggesting that dys-1 plays a role in the muscle response to acetylcholine; a chimeric transgene in which the C-terminal end of the elegans DYS-1 protein is replaced by the human dystrophin sequence is able to partly suppress the phenotype of the dys-1 mutants; however, the genetic model for progressive myopathy in C. elegans consists of the dys-1 mutation combined with a mutation in hlh-1, the MyoD ortholog (dys-1(cx18);hlh-1(cc561ts), these animals display time-dependent muscle degeneration; use of this model has identified several genes, that play a role in muscle degeneration, eg., dyc-1/nitric oxide synthase (nNOS)-binding protein CAPON. | Homo sapiens | Paper_evidence | WBPaper00003867 |
| | | | | Accession_evidence | OMIM | 300377 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 17 May 2017 00:00:00 |
| Models_disease_asserted (21) |
| Molecular_info | Corresponding_CDS | F15D3.1a |
| | | F15D3.1b |
| | | F15D3.1c |
| | | F15D3.1d |
| | | F15D3.1e |
| | | F15D3.1f |
| | | F15D3.1g |
| | | F15D3.1h |
| | | F15D3.1i |
| | | F15D3.1j |
| | Corresponding_CDS_history | F15D3.1a:wp47 |
| | Corresponding_transcript | F15D3.1a.1 |
| | | F15D3.1b.1 |
| | | F15D3.1c.1 |
| | | F15D3.1d.1 |
| | | F15D3.1e.1 |
| | | F15D3.1f.1 |
| | | F15D3.1g.1 |
| | | F15D3.1h.1 |
| | | F15D3.1i.1 |
| | | F15D3.1j.1 |
| | Other_sequence (44) |
| | Associated_feature (19) |
| Experimental_info | RNAi_result (13) |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00003169 |
| | | WBCnstr00010181 |
| | Construct_product | WBCnstr00007078 |
| | | WBCnstr00008412 |
| | | WBCnstr00010181 |
| | | WBCnstr00011497 |
| | Regulate_expr_cluster | WBPaper00028474:dys-1_downregulated |
| | | WBPaper00028474:dys-1_upregulated |
| | Antibody | WBAntibody00003001 |
| | Microarray_results (34) |
| | Expression_cluster | WBPaper00029359_1183 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1310 |
| | | WBPaper00029359_1362 |
| | | WBPaper00029359_1364 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1578 |
| | | WBPaper00029359_1604 |
| | | WBPaper00029359_1636 |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:bodywall-muscle_CoreEnriched |
| | | WBPaper00037950:bodywall-muscle_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00056139:gut-microbiota_downregulated |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059987:Wounding_downregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060871:M.humicola-extract_1h_regulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061285:wounding_24h_downregulated |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:DVC_parent |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVQ_parent |
| | | WBPaper00061527:T16H12.9-kin-9_20752 |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00061902:CAMT-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00063976:micu-1(bon20)_upregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064735:bet-1B(OE)mys-1(RNAi)_vs_mys-1(RNAi)_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00064992:heat-shock_upregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065841:1_1 |
| | | WBPaper00065841:4_0 |
| | | cgc4386_cluster_5_2 |
| | | cgc4489_group_13 |
| | | cgc4489_group_20 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00040184:hcf-1down_sir-2.1nc_daf-2nc |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_C |
| | Interaction (61) |
| Map_info | Map | I | Position | 9.11232 |
| | Positive | Positive_clone | F15D3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4272 |
| | | | 5386 |
| | Pseudo_map_position |
| Reference (86) |
| Remark | Sequence connection from [Segalat L] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| | [210510 skd] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (9.05343) |
| Method | Gene |
